Leading neuroscience researchers offer a fresh perspective on neuronal function by examining all its many components-including their pertubation during major disease states-and relate each element to neuronal demands. Topics range from the dependency of neurons on metabolic supply, as well as on both ion and transmitter homeostasis, to their close interaction with the myelin sheath. Also addressed are the astrocytic signaling system that controls synaptic transmission, the extracellular matrix and space as communication systems, the role of blood flow regulation in neuronal demand and in blood-brain barrier function, and inflammation and the neuroimmune system. Insightful and integrative, The Neuronal Environment: Brain Homeostasis in Health and Disease demonstrates a clear new understanding that neurons do not work in isolation, that they need constant interactions with other brain components to process information, and that they are not the only information processing system in the brain.

Includes supplementary material: sn.pub/extras

Klappentext
To function properly, neurons must interact with other constituent elements of the brain (e.g., blood supply and myelin), and in fact most diseases of the nervous system involve these nonneuronal components. In The Neuronal Environment: Brain Homeostasis in Health and Disease, leading neuroscience researchers offer a fresh perspective on neuronal function by examining all its many components-including their pertubation during major disease states-and relate each element to neuronal demands. Topics range from the dependency of neurons on metabolic supply, ion homeostasis, and transmitter homeostasis, to their close interaction with the myelin sheath. Also addressed are the astrocytic signaling system, which controls synaptic transmission, the extracellular matrix and space as communication systems, the role of blood flow regulation in blood-brain barrier function, and inflammation and the neuroimmune system. All these elements are treated in the context of their importance for neurons and the major diseases affecting them.
Insightful and integrative, The Neuronal Environment: Brain Homeostasis in Health and Disease demonstrates for today's neuroscientists, cell biologists, and pharmacologists a clear new understanding that neurons do not work in isolation, that they need constant interactions with other brain components to process information, and that they are not the brain's sole information processing system.

Inhalt
I. Neuronal Activity and its Dependence on the Microenvironment.- 1 Central Nervous System Microenvironment and Neuronal Excitability.- 2 Neuronal Energy Requirements.- II. Brain Microenvironment.- 3 Plasticity of the Extracellular Space.- 4 TransmitterReceptor Mismatches in Central Dopamine, Serotonin, and Neuropeptide Systems: Further Evidence for Volume Transmission.- 5 The Extracellular Matrix in Neural Development, Plasticity, and Regeneration.- 6 Homeostatic Properties of Astrocytes.- 7 GlutamateMediated AstrocyteNeuron Communication in Brain Physiology and Pathology.- 8 Axonal Conduction and Myelin.- 9 Coupling of Blood Flow to Neuronal Excitability.- III. Brain Macroenvironment.- 10 Choroid Plexus and the CerebrospinalInterstitial Fluid System.- 11 The Blood-Brain Barrier.- 12 Circumventricular Organs.- 13 Glial Linings of the Brain.- IV. Immune System-Neuron Interactions.- 14 Microglia in the CNS.- 15 Invasion of Ischemic Brain by Immune Cells.