Neurogenesis in the Adult Brain II illustrates major advances in the field of adult neurogenesis and their application to brain diseases therapies. The text provides up-to-date information on the mechanisms that regulate the proliferation, differentiation and survival of neural stem cells.

The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.

Historical account of the brilliant discoveries of the fathers of adult neurogenesis Detailed presentation of the anatomy, physiology, and molecular biology of adult neurogenesis Chapters on the clinical implications of adult neurogenesis Includes supplementary material: sn.pub/extras

Inhalt

1 Neurogenesis in Monkey and Human Adult Brain.- 2 Adult Neurogenesis in Parkinson's Disease.- 3 Adult Neurogenesis in Epilepsy.- 4 Stress Disorders.- 5 Depression.- 6 Impaired Neurogenesis as a Risk Factor for Schizophrenia and Related Mental Diseases.- 7 Neurogenesis from Endogenous Neural Stem Cells After Stroke: A Future Therapeutic Target to Promote Functional Restoration?.- 8 Perspectives of PUFA-GPR40 Signaling Crucial for Adult Hippocampal Neurogenesis.- 9 Adult Neurogenesis and Neuronal Subtype Specification in the Neocortex.- 10 Culturing Adult Neural Stem Cells: Application to the Study of Neurodegenerative and Neuropsychiatric Pathology.- Index.