This detailed volume aims to introduce nanomaterials as a new therapeutic regimen in treating human diseases. Divided into four sections, it explores inorganic nanomaterials, organic nanomaterials, pharmaceutical properties of nanomaterials, and applications of nanomaterials in medicine. Several examples of inorganic and organic nanomaterials are provided to demonstrate how to design and develop nanomaterials for pharmacological purposes. The key pharmaceutical properties, including biocompatibility, tissue interaction, pharmaceutics, and pharmacokinetics of nanomaterials are discussed with a focus on the safety and pharmaceutical considerations of nanomaterials in translational development. The pharmacological applications of nanomaterials are depicted in treating various human diseases, including cancer, cardiovascular diseases, immune disorders, infectious diseases, gastrointestinal disorders, bone diseases, respiratory disorders, and drug delivery. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of specifics and practical advice that ensures a smooth transition into the lab.

Authoritative and enlightening, Nanomaterials in Pharmacology serves as an ideal guide to researchers investigating the potential benefits and risks of nanomaterials in pharmacology in order to avoid the pitfalls and to maximize the potential of this vital field of study.

Examines nanomaterials as a new therapeutic regimen in treating human diseases Features practical approaches to this area of study Includes contributions from experts in the field with key implementation advice

Inhalt

Synthetic Polymer-Based Nanomaterials.- Cyclodextrin-Based Drug Carriers for Low Molecular Weight Drugs, Proteins, and Nucleic Acids.- Development of Dendrimer-Based Nanomaterials for Diagnostic and Therapeutic Applications.- Paving the Way Toward Translational Application of Virus-Based Nanoparticles (VNPs): Preclinical Evaluation of Their Biological Fates.- Gold Nanoparticles for Biomedical Applications: Synthesis and In Vitro Evaluation.- Paramagnetic Nanoparticles.- Silica Nanomaterials.- Silicon Nano- and Microparticles.- Biocompatibility of Nanomaterials.- Nanoparticle-Tissue Interaction.- Pharmaceutics of Nanoparticles.- Pharmacokinetic Properties of Nanomaterials.- Cardiovascular Nanomedicine: Materials and Technologies.- Gastrointestinal System.- Respiratory System.- Depot Microcapsules Containing Biologic Nanoparticles and Cytoplasm-Responsive Nanocarriers for Nucleotides.- Nanoparticulate Drug Delivery Systems to Overcome the Blood-Brain Barrier.- Transcutaneous Immunization Using Nano-Sized Drug Carriers.- Nanomaterials for Treating Ocular Diseases.- Nanomedicine for the Treatment of Musculoskeletal Diseases.- Synthetic Polymeric Nanoparticles for Immunomodulation.- Nanomedicine and Infection.- Cancer Therapy with Nanotechnology-Based Drug Delivery Systems: Applications and Challenges of Liposome Technologies for Advanced Cancer Therapy.