Myofibrillogenesis has been studied extensively over the last 100 years. Recent advances in molecular techniques combined with classical embryology as well as cell biology have started to unravel some of the complexities of myofibril assembly in vertebrate heart/striated muscles. This volume is a comprehensive reference to the various aspects of myofibrillogenesis in vertebrates. "Myofibrillogenesis" will prove valuable to researchers and students in the field of striated and cardiac muscle.

Autorentext
Myofibrillogenesis has been studied extensively over the last 100
years. Recent advances in molecular techniques combined with classical
embryology as well as cell biology have started to unravel some of the
complexities of myofibril assembly in vertebrate heart/striated
muscles. This volume is a comprehensive reference to the various
aspects of myofibrillogenesis in vertebrates. "Myofibrillogenesis"
will prove valuable to researchers and students in the field of
striated and cardiac muscle.

Inhalt
I: Assembly of Myofibrillar Proteins in Striated Muscle.- 1. Myofibrillogenesis in Cardiac Muscle.- 2. Dynamics of Contractile Proteins Constituting Myofibrils in Living Muscle Cells.- 3. Emergence of the First Myofibrils and Targeting Mechanisms Directing Sarcomere Assembly in Developing Cardiomyocytes.- 4. Tropomodulin: An Important Player in Cardiac Myofibrillogenesis.- II: Maintenance and Manipulation of Myofibrillar Organization.- 5. Maintaining the Fully Differentiated Cardiac Sarcomere.- 6. Manipulation of Myofibrillogenesis in Whole Hearts.- III: Regulation of Expression of Myofibrillar Proteins.- 7. Molecular Regulation of Cardiac Myofibrillogenesis: Roles of Serum Response Factor Nkx2-5, and GATA-4.- 8. Regulation and Organization of Human Troponin Genes.- 9. Signal Transduction in Myofibrillogenesis Cell Growth, and Hypertrophy.- 10. Cytoskeletal Gene Expression in the Developing Cardiac Conduction System.- IV: Heart Development and Myofibrillar Organization.- 11. Onset of a Cardiac Phenotype in the Early Embryo.- 12. Cellular Molecular, and Developmental Studies on Heart Development in Normal and Cardiac Mutant AxolotlsAmbystoma mexicanum.- V: Cardiomyopathy and Myofibrillar Organization.- 13. The Function of Normal and Familial Hypertrophic CardiomyopathyAssociated Tropomyosin.- 14. Cardiomyopathies and Myofibril Abnormalities.