This is the first comprehensive treatise that deals with the formation of blood vessels during embryonic development. Assembly of the Vasculature and its Regulation presents the most current understanding of vascular angiogenesis and vasculogenesis at the molecular scale. Addressed are recent discoveries in growth factors, adhesion molecules, extracellular components, signaling pathways, and smooth muscle differentiation, beginning with molecular mechanisms and broadening to the development of major organs. The book is an important reference work for all students and researchers working in vascular biology.

Inhalt

1. The Development of Blood Vessels: Cellular and Molecular Mechanisms.- 2. The Role of Vascular Endothelial Growth Factors and Their Receptors During Embryonic Vascular Development.- 3. The Ties That Bind: Emerging Concepts About the Structure and Function of Angiopoietins and Their Receptors in Angiogenesis.- 4. Extracellular Matrix in the Regulation of Angiogenesis.- 5. The Role of Cell Adhesion Receptors in Vascular Development: An Overview.- 6. Development and Differentiation of Vascular Smooth Muscle.- 7. Vascular Development of the Heart.- 8. Vascular Development of the Brain and Spinal Cord.- 9. Vascular Development of the Kidney.- 10. Vascular Development of the Lung.- 11. Vascularization of the Placenta.