This book reviews recent advances in pancreatic endocrine and exocrine tissue development, function and regeneration. It provides a comprehensive overview on different aspects of beta-cell biology, including heterogeneity of function and gene expression and function, epigenetics, RNA and protein expression contributions to beta-cell specification and cell-fate maintenance. Furthermore, it covers recent progress in differentiating functional islets in vivo , ** environmental impacts on beta-cell development and function, and communications between various islet endocrine cells and how they contribute to the regulation of blood glucose homeostasis. The book provides a comprehensive resource for understanding the various compartments of the pancreas and is aimed at pancreas, beta-cell biology, and diabetes researchers.

Reviews recent advances in pancreatic endocrine and exocrine tissue development Includes simple models helping to understand complex emergent concepts and techniques Covers new findings in beta cell research in one place

Autorentext

Dr. Maria Golson graduated from Duke University with a B.S. in Biology in 2000. She focused on pancreas development in her studies as a graduate student in the Cell and Molecular Biology Program at the University of Pennsylvania and graduated with a Ph.D. in 2008. She furthered her expertise in the beta-cell biology field at the Vanderbilt University as a postdoctoral fellow studying with Maureen Gannon. Starting in 2015, she followed up with a stint as a Research Assistant Professor in the Genetics Department at the University of Pennsylvania, where she coordinated the Human Pancreas Analysis Program under Klaus Kaestner while also studying the regulation of beta-cell function by intrinsic and extrinsic factors. In 2020, Dr. Golson joined the faculty in the Division of Endocrinology, Diabetes, and Metabolism at the Johns Hopkins University as an Asisstant Professor.

Inhalt
Alpha Cell Contribution to Glucose Homeostasis.- Delta Cell Contribution to Glucose Homeostasis.- Islet Cell Plasticity Including Beta-Cell DedifferentiationCombined with Beta-Cell Heterogeneity.- Epigenetic Regulation of Pancreas Development and Function.- Beta-Cell Differentiation in vitro.- Endocrine Pancreas Regeneration.- Ductal Cell Development.- Relationship Between Beta-Cell Function and Beta-Cell Proliferation.- Maternal and Paternal Environmental Impacts on Beta-Cell Development.- Beyond Sugar: How Fat and Protein Contribute to the Regulation of Insulin Secretion.- Channels Involved in Regulating Insulin Secretion.