Investigation of the morphology and function of lym phatic tissue evolved rapidly during the past few years. Many new aspects and dimensions have proved to be of gre at significance for the understanding of processes which are triggered by immunological means. The cellular coor dination that operates in immune response emphasizes aga in the importance of immuno-ecologic relations in the lymphatic tissue. It has become obvious that both the morphologic and the molecular properties of lymphatic cells are essential for their functional expression. Furthermore, the emerging body of evidence clearly shows that nonlymphatic cells (e.g. reticular cells and neu rons) and substances that exert neurohumoral and hormo nal activities should be regarded as normal constituents of the microenvironment of lymphatic tissue. The immune phenomena are, therefore, direct derivates of processes that occur in this microenvironment. Such a view of the microenvironment of immunity calls for immunoendocrino logic, immunoneurologic and immunopharmacologic projects, it stimulates the creative imagination, and encourages research workers to enter into unexplored areas of the immunosciences. This book illustrates the joint efforts made by scientists from various parts of the world and armed with different ideas and views, to solve some of the mysteries of lymphatic tissue microenvironment. The Fourth Conference took place in the lovely set ting of Dubrovnik and in the shade of olive trees under which philosophers used to meditate in ancient times.

Klappentext

Investigation of the morphology and function of lym­ phatic tissue evolved rapidly during the past few years. Many new aspects and dimensions have proved to be of gre­ at significance for the understanding of processes which are triggered by immunological means. The cellular coor­ dination that operates in immune response emphasizes aga­ in the importance of immuno-ecologic relations in the lymphatic tissue. It has become obvious that both the morphologic and the molecular properties of lymphatic cells are essential for their functional expression. Furthermore, the emerging body of evidence clearly shows that nonlymphatic cells (e.g. reticular cells and neu­ rons) and substances that exert neurohumoral and hormo­ nal activities should be regarded as normal constituents of the microenvironment of lymphatic tissue. The immune phenomena are, therefore, direct derivates of processes that occur in this microenvironment. Such a view of the microenvironment of immunity calls for immunoendocrino­ logic, immunoneurologic and immunopharmacologic projects, it stimulates the creative imagination, and encourages research workers to enter into unexplored areas of the immunosciences. This book illustrates the joint efforts made by scientists from various parts of the world and armed with different ideas and views, to solve some of the mysteries of lymphatic tissue microenvironment. The Fourth Conference took place in the lovely set­ ting of Dubrovnik and in the shade of olive trees under which philosophers used to meditate in ancient times.

Inhalt
Opening Remark.- Structural Correlates of Immune Microenvironment.- Session 1 Microenvironmental Aspects of Lymphatic Tissue.- Introduction: Microenvironments in the Lymphoid System.- Differentiation of B Lymphocytes from Stem Cell Precursors.- Hemopoietic Origin of B Cells in the Mouse.- Lymphocyte Differentiation in the Chicken Embryo Relationship to the Microenvironment.- The Lymphoid Development of the Embryonic Chicken Thymus in Organ Culture.- Colonizing Capacity of Lymphoid Cells Injected into Syngeneic Hosts.- Differential Traffic Patterns of T and B Lymphocytes in Relation to Germinal Centre Development.- Ecotaxis of B Cells in the Mouse.- Homing of B-Lymphocytes to Follicles: Specific Retention of Immunologically Committed Cells.- Antigenic Markers on Lymphoid Cells Varying in Their Capacity to Recirculate.- Thymus Cell Migration: 3HTdR-Labeled and Theta-Positive Cells in Peripheral Lymphoid Tissues of Newborn Mice.- Lymph Node Function and Lymphocyte Circulation in the Pig.- Germinal Centers: A Microenvironment for the Production of Antibody Forming Precursors?.- Microenvironmental Aspects of Lymphatic Tissue: Summary.- Session 2 Interaction of Lymphatic Cells.- Introduction: Cell Cooperation in Antibody Production A Perspective with Questions.- Functional Heterogeneity of Thymus-Derived Lymphocytes.- Some Cell Surface Properties of Thymus-Derived Lymphocytes in Bursectomized Chickens.- Studies on the Influence of T Cells in Antibody Responses of Mice to SIII and DNP-Lysine-SIII.- Induction of Anti-Hapten Antibody Responses against Haptens Conjugated to Autologous and Heterologous Proteins.- Contribution of B and T Lymphocytes to in vitro Chicken Proliferative Spleen Cell Reactions to Antigens.- Proliferation of Activated Thymocytes in MixedLymphocyte Reactions.- Lymphoid Cell Interactions in Cell-Mediated Immunity.- Appendix and Thymus Cell Synergism in the Direct and Indirect Plaque Forming Cell Response to Sheep Erythrocytes.- The Role of Soluble Factors in T-B Cell Collaboration.- Studies on the Source and Action of the T-Cell Replacing Factor (TRF).- Thymus Extracts Induce Differentiation of Thymus Derived Cells.- Interaction of Lymphatic Cells: Summary.- Session 3 Antigen Recognizing and Processing Cells.- Introduction: Antigen Recognizing and Processing Cells.- Immunoglobulin Surface Determinants on Chicken Lymphoid Cells.- Functional and Morphologic Characteristics of Complement Receptor Lymphocytes in Mice.- Stimulation of Mouse Thymocytes by Syngeneic Spleen Cells in Mixed Lymphocyte Reactions.- Differential Induction and Suppression of Direct and Indirect PFC Responses to TNP Conjugated to Heterologous Erythrocytes.- Reconstitution of Primary Response in vitro by Defined Peritoneal Cells.- Uptake and Degradation of a Synthetic Antigen by Mouse Macrophages Containing Different Levels of Lysosomal Enzymes.- Direct Evidence for Plaque Formation by Macrophages.- The Proportion of Lymphocytes Capable of Recognizing Strong Transplantation Antigens in vivo.- Recovery of the Immune Response after Depletion of Specific Cells.- Early Appearance of Antigen-Binding Cells to Two Different Antigens during Fetal Lymphoid Development.- Antigen Recognizing and Processing Cells: Summary.- Session 4 Cellular Aspects of Immune Deficiency Diseases.- Introduction: Cellular Aspects of Immune Deficiency Diseases Involving B Cells.- Enhancement of the Immune Response of Genetically Thymus-Less Mice by Different Cell Populations.- Thymus Factors and Immunity: Enhancement of Immunologic Maturation by a Purified Calf Thymus Extract.- Involution of the Thymus Dependent Lymphoid System.- A Study on Human T Lymphocytes, Their Function and Frequency in Some Diseases.- Evidence of Two Functionally Distinct Lymphocyte Populations in Man.- The Relation between Nutritional Deprivation and Immunity.- Combined System Immunodeficiency with DiGeorge Syndrome and Dissociation of PHA/MLC Responses.- Transplantation of Haemopoietic Stem Cell (HSC) Concentrates for Treatment of Immune Deficiency Disease.- Immunological and Clinical Effects of Transfer Factor in Anergic Subjects.- Cellular Aspects of Immune Deficiency Diseases: Summary.- Session 5 Lymphatic Tissue in Tolerance, Immunosuppression and Facilitation.- Introduction: Different Types of Immunological Unresponsiveness.- Mechanism of Antigen Binding to Receptor Antibody in B Cell Immunity and Tolerance in vitro.- Characteristics of B Cell Tolerance Induced with T-Independent Polysaccharides.- Cortisone Interfering with the Production of T and B Cells.- Immunosuppression of the Thymectomized Fetal Lamb and Its Neonatal Reconstitution.- Antigen Recognition and Localization in RES Blockaded Mice: Morphologic and Immunologic Studies.- The Effect of Cyclophosphamide on the Primary Humoral Immune Response. The Immunological Priming.- Germin…