Micro and Nano Flow Systems for Bioanalysis

This book addresses the latest developments in biomedical engineering at very small scales and shows how organic systems require multi-scale understanding on the basis of both experimental and mathematical approaches and both healthy and diseased states.

Micro and Nano Flow Systems for Bioanalysis addresses the latest developments in biomedical engineering at very small scales. It shows how organic systems require multi-scale understanding in the broadest sensewhether the approach is experimental or mathematical, and whether the physiological state is healthy or diseased. Micro-and nano-fluidics represent key areas of translational research in which state-of-the-art engineering processes and devices are applied to bedside monitoring and treatment. By applying conventional micro- and nano-engineering to complex organic solids, fluids, and their interactions, leading researchers from throughout the world describe methods and techniques with great potential for use in medicine and clinical practice. Coverage includes the seeming plethora of new, fine-scale optical methods for measuring blood flow as well as endothelial activation and interaction with tissue. Generic areas of modeling and bioelectronics are also considered. In keeping with the recurring theme of medicine and clinical practice, approximately half of the chapters focus on the specific application of micro- and nano- flow systems to the understanding and treatment of cancer and cardiovascular diseases. This book developed from an Expert Overview Session on "Micro & Nano Flows in Medicine: the way ahead" at the 3rd Micro and Nano Flows Conference (MNF2011) held in Thessaloniki, Greece. Additional chapters were included to enhance the international, state-of-the-art coverage.

Covers a broad range of topics, including ultrascale optical measurement methods and the modeling of multiscale biomedical flows Explains the underlying biology in areas such as cascades of reacting agents Includes applications to cardiology and to the detection and treatment of cancer Provides an overview suitable for a broad audience of bioengineering researchers, students, and clinicians

Autorentext

Micro- and Nano- Flow Systems for Bioanalysis addresses the latest developments in biomedical engineering at very small scales. It shows how organic systems require multi-scale understanding in the broadest sensewhether the approach is experimental or mathematical, and whether the physiological state is healthy or diseased. Micro-and nano-fluidics represent key areas of translational research in which state-of-the-art engineering processes and devices are applied to bedside monitoring and treatment. By applying conventional micro- and nano-engineering to complex organic solids, fluids, and their interactions, leading researchers from throughout the world describe methods and techniques with great potential for use in medicine and clinical practice. Coverage includes the seeming plethora of new, fine-scale optical methods for measuring blood flow as well as endothelial activation and interaction with tissue. Generic areas of modeling and bioelectronics are also considered. In keeping with the recurring theme of medicine and clinical practice, approximately half of the chapters focus on the specific application of micro- and nano- flow systems to the understanding and treatment of cancer and cardiovascular diseases. This book developed from an Expert Overview Session on "Micro & Nano Flows in Medicine: the way ahead" at the 3rd Micro and Nano Flows Conference (MNF2011) held in Thessaloniki, Greece. Additional chapters were included to enhance the international, state-of-the-art coverage.

Klappentext

Micro and Nano Flow Systems for Bioanalysis addresses the latest developments in biomedical engineering at very small scales. It shows how organic systems require multi-scale understanding in the broadest sense whether the approach is experimental or mathematical, and whether the physiological state is healthy or diseased. Micro-and nano-fluidics represent key areas of translational research in which state-of-the-art engineering processes and devices are applied to bedside monitoring and treatment. By applying conventional micro- and nano-engineering to complex organic solids, fluids, and their interactions, leading researchers from throughout the world describe methods and techniques with great potential for use in medicine and clinical practice. Coverage includes the seeming plethora of new, fine-scale optical methods for measuring blood flow as well as endothelial activation and interaction with tissue. Generic areas of modeling and bioelectronics are also considered. In keeping with the recurring theme of medicine and clinical practice, approximately half of the chapters focus on the specific application of micro- and nano- flow systems to the understanding and treatment of cancer and cardiovascular diseases. This book developed from an Expert Overview Session on "Micro & Nano Flows in Medicine: the way ahead" at the 3rd Micro and Nano Flows Conference (MNF2011) held in Thessaloniki, Greece. Additional chapters were included to enhance the international, state-of-the-art coverage.

Covers a broad range of topics, including ultrascale optical measurement methods and the modeling of multiscale biomedical flows

Explains the underlying biology in areas such as cascades of reacting agents

Includes applications to cardiology and to the detection and treatment of cancer

Provides an overview suitable for a broad audience of bioengineering researchers, students, and clinicians

Inhalt
1: Iron Oxide Nanoparticles and Derivatives for Biomedical Imaging and Application in Cancer Diagnosis and siRNA Therapy.- 2: Inertial migration of cancer cells in a micro-fluidic device.- 3: 3D Multiscale Modelling of Angiogenesis and Vascular Tumour Growth.- 4: Microvascular permeability and Tumor metastasis.- 5: Micro flows in the Cardio-Pulmonary system: a surgical perspective.- 6 : Regulation of endothelial activation & vascular inflammation by shear stress.- 7: Digital optical and scanning probe microscopy for biocell inspection and manipulation.- 8: Coherent microscopy and Optical Coherence Tomography for biomedical applications.- 9: Confocal micro-PIV/PTV measurements of the blood flow in micro-channels.- 10: The Lattice Boltzmann method as a general framework for blood flow modelling and simulations.- 11: Dielectrophoretic characterization and continuous separation of cells in a PDMS microfluidic device with sidewall conducting PDMS composite electrodes.- 12: Integrating Omics Data for Quantitative and Systems Pharmacology in Translational Oncology