Although primarily used today as one of the most prevalent illicit leisure drugs, the use of Cannabis sativa L., commonly referred to as marijuana, for medicinal purposes has been reported for more than 5000 years. Marijuana use has been shown to create numerous health problems, and, consequently, the expanding use beyond medical purposes into recreational use (abuse) resulted in control of the drug through international treaties. Much research has been carried out over the past few decades following the identification of the chemical structure of THC in 1964. The purpose of Marijuana and the Cannabinoids is to present in a single volume the comprehensive knowledge and experience of renowned researchers and scientists. Each chapter is written independently by an expert in his/her field of endeavor, ranging from the botany, the constituents, the chemistry and pharmacokinetics, the effects and consequences of illicit use on the human body, to the therapeutic potential of the cannabinoids.

Includes supplementary material: sn.pub/extras

Klappentext

Marijuana and the Cannabinoids presents a compendium of research into the botany, chemistry, and pharmacology of cannabis and the medicinal aspects of the cannabinoids. While medicinal use of Cannabis sativa L. has been reported for over 5000 years, interest in its medicinal potential and controversy surrounding its illicit use have grown exponentially since the identification of the chemical structure of the plant's active constituent (D9-THC) in 1964. This volume presents the findings of researchers on the forefront of this emerging and controversial field of study. Chapter 1 is an overview of Cannabis and natural Cannabis medicines, while Chapter 2 focuses on the chemistry and analysis of phytocannabinoids and other Cannabis constituents. Chapter 3 discusses the potential of chemical fingerprinting of Cannabis as a means for source identification, and Chapters 4 and 5 outline the chemistry and pharmacology of cannabinoids and marijuana smoke condensate. In Chapter 6, the endocannabinoid system and the therapeutic potential of cannabinoids is presented. Chapter 7 provides technologies, development strategies, and multilevel applications for immunoassays for the detection of Cannabis abuse. In Chapter 8, mass spectrometric methods for the analysis of cannabinoids in physiological specimens are described. Chapters 9-12 discuss various consequences and adverse effects of prolonged marijuana use, including medical and health concerns and driving impairments. Chapters 13 and 14 examine postmortem considerations and the effects of cannabinoids on biopsychological, neuropsychiatric, and neurological processes.

Inhalt
Cannabis and Natural Cannabis Medicines.- Chemistry and Analysis of Phytocannabinoids and Other Cannabis Constituents.- Chemical Fingerprinting of Cannabis as a Means of Source Identification.- Marijuana Smoke Condensate.- Pharmacology of Cannabinoids.- The Endocannabinoid System and the Therapeutic Potential of Cannabinoids.- Immunoassays for the Detection of Cannabis Abuse.- Mass Spectrometric Methods for Determination of Cannabinoids in Physiological Specimens.- Human Cannabinoid Pharmacokinetics and Interpretation of Cannabinoid Concentrations in Biological Fluids and Tissues.- Medical and Health Consequences of Marijuana.- Effects of Marijuana on the Lung and Immune Defenses.- Marijuana and Driving Impairment.- Postmortem Considerations.- Cannabinoid Effects on Biopsychological, Neuropsychiatric, and Neurological Processes.