Summarizes the latest studies on intracellular events during filovirus infection

Focuses on mechanisms of viral entry and receptor binding, assembly of the viral particles inside the cell, and the use of reverse genetic systems

Explains recent advances in our understnding of filovirus disease, pathology in the NHP model, and the development of new small animal models to study filovirus infectionn

Autorentext
Elke MühlbergerBoston University School of Medicine
Boston, MA, USAe-mail: muehlber@bu.edu
Lisa L. HensleyNational Institutes of HealthNIAID
Frederick, MD, USA
e-mail: Lisa.Hensley@nih.gov
Jonathan S. TownerCenters for Disease Control & PreventionAtlanta, GA, USA
e-mail: jit8@cdc.gov

Inhalt
Filovirus Research: How it began.- Ecology of Filoviruses.- West Africa 2013 Ebola: From Virus Outbreak to Humanitarian Crisis.- Clinical Management of Ebola Virus Disease Patients in Low Resource Settings.- Clinical Management of Patients with Ebola Virus Disease in High Resource Settings.- Ebola Virus Disease in Humans: Pathophysiology and Immunity.- Nonhuman Primate Models of Ebola Virus Disease.- Small Animal Models for Studying Filovirus Pathogenesis.- Accelerating Vaccine Development during the West African Ebola Virus Disease Outbreak.- Therapeutics against Filovirus Infection.- Filovirus Strategies to Escape Antiviral Responses.- Mechanisms of Filovirus Entry.- Inside the Cell: Assembly of Filoviruses.- Filovirus Structural Biology: The Molecules in the Machine.- Reverse Genetics of Filoviruses.- Guide to the Correct Use of Filoviral Nomenclature.