This volume reviews the current research focused on the functional importance of unfolded protein response (UPR) signaling in the context of health and disease. The chapters present cutting-edge work describing the diverse functions of UPR signaling critical for regulating cellular and organismal physiology under physiologic and pathologic conditions. Written by internationally respected scientists, this volume is designed to provide a broad view of the diverse functional importance of UPR, and as such appeals to clinicians and academic researchers alike.

Highlights the importance of UPR signaling in regulating endoplasmic reticulum function Examines how imbalances in UPR signaling can influence human disease pathogenesis Discusses therapeutic potential for UPR-dependent remodeling of ER proteostasis to intervene in etiologically diverse human diseases

Autorentext

R. Luke Wiseman

Associate Professor

Department of Molecular Medicine

The Scripps Research Institute MEM 220

La Jolla, CA 92037, USA

Phone: (858) 784-8820 Email: wiseman@scripps.edu

Cole M. Haynes

Associate Professor

University of Massachusetts Medical School

Worcester, MA 01605, USA

Email:Cole.Haynes@umassmed.edu

Inhalt

Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response.- Cell Non-Autonomous UPR ER Signaling.- The unfolded protein response in the immune cell development: Putting the caretaker in the driving seat.- Mitochondria associated membranes and ER stress.- Coordinating Organismal Metabolism during Protein Misfolding in the ER Through the Unfolded Protein Response.- ER stress and neurodegenerative disease: a cause or effect relationship?- Driving cancer tumorigenesis and metastasis through UPR signaling.- ER Protein Quality Control and the Unfolded Protein Response in the Heart.