A path-breaking and comprehensive review of the pathophysiology and management of patients with acute coronary syndromes (ACS). Drawing on the key results of recent clinical trials, world-renowned clinicians and clinical investigators establish state-of-the-art management guidelines for patients with ST-elevation MI or non-ST-elevation ACS. Their discussion includes a detailed review of the pathophysiology of ACS and a survey of the diagnostic tools available to assess patients. Management of Acute Coronary Syndromes captures the major advances that have occurred in our understanding of the pathophysiology, diagnosis, and management of patients with acute coronary syndromes. This book is certain to help cardiologists, primary physicians, emergency medicine physicians, and many others to better serve their patients with today's most efficacious treatments.

Zusammenfassung
Foreword by Eugene Braunwald, MD

"The review of the data on the diagnostic and prognostic utility of serum markers of cardiac injury is especially thorough. The treatments of thrombolytic therapy and primary angioplasty for acute myocardial infarction are complete, timely, and objective...[the] section on special aspects of acute coronary syndromes summarizes well the important issues of gender bias (or lack thereof) in cardiovascular medicine and the impact of lowering cholesterol." -Annals of Internal Medicine, 18 May 1999, Reviewer: Warren Laskey, MD

"...a thorough, wide-ranging review of the current knowledge on ACS...a valuable resource for cardiologists and emergency physicians." -Circulation

"This is an excellent and concise review of the spectrum of unstable angina, ST segment elevation infarction, and ST segment depression infarction...It spends a good deal of time on explaining the serum markers for myocardial ischemia as well as their pathophysiologic differences between ST elevation and ST depression infarction and the rationale for specific treatment strategies. Data on primary angioplasty and the thrombolytic trials are reviewed in detail...The numerous tables and charts are well designed and emphasize important topics covered in the text...This book is an excellent summary of acute coronary syndromes. It is well thought out and easy to read, which allows the reader to assimilate a lot of information in a short period of time. Its clear writing and effective use of tables and graphics solidifies understanding this essential topic in cardiology."-5 stars, Doody's Health Sciences Book Review Journal

"...an outstanding compendium of what is currently known about the etiology, diagnosis, and treatment of acute coronary syndromes....The chapter references are extensive and up-to-date. The illustration, tables and charts are well done and easily interpreted...In summary, this is an outstanding work that should be on the reading list of everyone who deals with cardiac care. Emergency physicians and cardiologists should read it from cover to cover and there is something for everyone here." -The Journal of Emergency Medicine

"This is an excellent and concise review of the spectrum of unstable angina, ST segment elevation infarction, and ST segment depression infarction. . .It spends a good deal of time on explaining the serum markers for myocardial ischemia as well as their pathophysiologic differences between ST elevation and ST depression infarction and the rationale for specific treatment strategies. Data on primary angioplasty and the thrombolytic trials are reviewed in detail...The numerous tables and charts are well designed and emphasize important topics covered in the text...This book is an excellent summary of acute coronary syndromes. It is well thought out and easy to read, which allows the reader to assimilate a lot of information in a short period of time. Its clear writing and effective use of tables and graphics solidifies understanding this essential topic in cardiology."-5 stars, Doody's Health Sciences Book Review Journal

Inhalt

Part I. Pathophysiology. The Spectrum of Myocardial Ischemia: The Paradigm of Acute Coronary Syndromes, Christopher P. Cannon, MD and Eugene Braunwald, MD. Linking Biochemical, Pathologic, and Clinical Events in Acute Coronary Syndromes, Richard C. Becker, MD. Triggers of Acute Coronary Syndromes, Peter M. Sapin, MD and James E. Muller, MD. Insights into the Pathophysiology of Acute Coronary Syndromes Using the TIMI Flow Grade and TIMI Frame Counting Methods, C. Michael Gibson, MD, Mukesh Goel, MD, Kathryn Ryan, MD, Michael Rizzo, MD, and Susan J. Marble, MD. Part II. Diagnosis. Identifying Acute Cardiac Ischemia in the Emergency Department, J. Hector Pope, MD and Harry P. Selker, MD. Early Identification and Treatment of Patients with Acute Coronary Syndromes, Costas T. Lambrew, MD. Serum Markers for Diagnosis and Risk Stratification in Acute Coronary Syndromes, L. Kristin Newby, MD, W. Brian Gibler, MD, Robert H. Christenson, MD, and E. Magnus Ohman, MD. Technologies to Diagnose Acute Ischemia, Robert J. Zalenski, MD and Harry P. Selker, MD. Part III. ST Segment Elevation Myocardial Infarction. Thrombolytic Therapy for ST Segment Elevation in Acute Myocardial Infarction, Jeffrey L. Anderson, MD, and Sanjeev Trehan. New Thrombolytic Agents, Uwe Zeyer, MD and Karl-Ludwig Neuhaus, MD. Primary Angioplasty, Sorin J. Brener, MD and Eric J. Topol, MD. Antiplatelet and Antithrombotic Therapy, Marc S. Sabatine, MD, and Ik-Kyung Jang, MD. ß-Adrenergic Blockers, Calcium-Channel Blockers, and Nitrates, Peter Stone, MD. Angiotensin-Converting Enzyme Inhibitors in Acute Coronary Syndromes, Antonio Rosado, MD and Gervasio A. Lamas, MD. Risk Stratification: Exercise Testing, Imaging, and Cardiac Catheterization, Sanjeev Puri, MD and Bernard Chaitman, MD. Part IV.Non-ST Segment Elevation Myocardial Infarction. Antithrombotic Therapy in Unstable Angina and Non-Q-Wave Myocardial Infarction, Marc Cohen, MD and Reginald Blaber, MD. Novel Antiplatelet and Antithrombotic Agents in the Treatment of Non-ST-Segment Elevation Coronary Ischemia, M. Musa Khan, MD and Neal S. Kleiman, MD. Thrombolytics and Invasive vs Conservative Strategies, Shilpesh S. Patel, MD and H. Vernon Andeson, MD. New Device Strategies in the Management of Acute Coronary Syndromes, Mukesh Goel, MD, Anthony M. Anderson, MD, John Moynihan, MD, Mike Kelley, MD, and C. Michael Gibson, MD. Part V. Special Aspects of Acute Coronary Syndromes. Women and Acute Coronary Syndromes, Alice K. Jacobs, MD. Myocardial Infarction in the Younger Patient, Jorge Plutzky, MD. Aggressive Management of Cardiogenic Shock, Gary E. Lane, MD and David R. Holmes, Jr, MD. Cholesterol Lowering, Terje R. Pedersen, MD. Secondary Prevention of Myocardial Infarction, Jorge Plutzky, MD. Cost-Effectiveness Analysis and the Treatment of Acute Coronary Syndromes, Harlan M. Krumholz, MD. Critical Pathways for Acute Coronary Syndromes, Christopher P. Cannon, MD and Patrick T. O'Gara, MD. Index.