This text provides a comprehensive summary of research and findings that have lead to the current understanding of the subventricular zones. It provides an overview of the roles of subventricular zones in normal development and in disease and a foundation from which current and future studies can be evaluated.

This research has enormous implications for a variety of diseases and disorders that result from or cause destruction of brain cells: degenerative diseases (e.g., Alzheimer's and Parkinson's diseases), cell destruction in the brain due to radiation and chemotherapy, traumatic brain injury, hypoxia and ischemia, infectious (e.g., aseptic meningitis) and demyelinating (e.g., multiple sclerosis) diseases, and alcoholism Includes supplementary material: sn.pub/extras

Inhalt
Cellular Heterogeneity of the Neonatal SVZ and its Contributions to Forebrain Neurogenesis and Gliogenesis.- Extrinsic and Intrinsic Factors Modulating Proliferation and Self-renewal of Multipotential CNS Progenitors and Adult Neural Stem Cells of the Subventricular Zone.- Birth, Migration and Function of SVZ-derived Neurons in the Adult Brain.- Contributions of the Neocortical Svz to Human Brain Development.- Responses of the Adult SVZ to Neuronal Death and Injury.- Responses of the SVZ to Radiation and Chemotherapy.- The Subventricular Zone Responds Dynamically to Mechanical Brain Injuries.- Responses of the SVZ to Hypoxia and Hypoxia/Ischemia.- Responses of the SVZ to Demyelinating Diseases.- Auxiliary Proliferative Zones in the Developing and Adult Central Nervous System: Lessons from Studies on the Effects of Ethanol.