This book focuses on energy metabolism and brain functions related to Cortical Spreading Depression of Leao (CSD), an important issue in brain pathophysiology. The first part of the book offers a comprehensive overview of the history and early research on CSD, and then discusses the recent advances in the technology used to map and monitor brain mitochondrial NADH redox state and other physiological functions during CSD. The chapters explore the connection between CSD and mitochondrial function under hypoxia, Ischemia and various drugs treatment, and provide a resource to scientists researching the development of CSD during various brain pathophysiological conditions.

This book is essential to scientists and students working in the field of bioenergetics of the brain and various organs and tissues in the body. The use of this technology is also crucial and applicable in the neuroscience field.

Describes in detail the connection between CSD and mitochondrial function Synthesizes our knowledge and understanding of CSD Provides real-time physiological mapping of brain funcitons in vivo

Autorentext

Dr. Avraham Mayevsky is a Professor Emeritus in The Mina & Everard Goodman Faculty of Life Sciences and the Leslie and Susan Gonda Multidisciplinary Brain Research Center at Bar-Ilan University in Ramat-Gan, Israel.

Dr Avraham Mayevsky's field of research since they started their Post-Doc training with Prof. Britton Chance in 1972, was Energy metabolism, including mitochondrial function in vivo, of the brain mainly and other tissues In Vivo, exposed to various pathophysiological conditions. During the 50 years of activity they were able to accomplish a large number of goals that have a very significant impact on the understanding of pathophysiological processes in the brain and other organs evaluated under In Vivo conditions. His vision was to develop experimental approaches and tools that will enable them to study various physiological processes in experimental animals and at the same time, will be ready for clinical applications. During the years Dr Mayevsky's laboratory published more than 60 papers dealing with the subject of Cortical Spreading Depression of Leao (CSD).

Dr. Judith Sonn was a part of the Mina & Everard Goodman Faculty of Life Sciences and the Leslie and Susan Gonda Multidisciplinary Brain Research Center at Bar-Ilan University in Ramat-Gan, Israel, for 45 years and retired in 2017.

After graduation, Dr Judith Sonn was a laboratory Manager in Prof. Joseph Kedem s laboratory, which investigated the physiology of the cardiovascular system. She continued to study for the master s degree under the supervision of Professor Kedem. The M.Sc. thesis (1979, Summa Cum Laude) was "Oxygen Balance in the Myocardium". This research approach helped to evaluate the myocardial oxygen balance In-Vivo which was described in about 15 articles.

In 1991 Dr Judith Sonn joined Professor Avraham Mayevsky s research team and as a Ph.D. student under his Supervision. The Doctoral dissertation (1996) was Effect of Spreading Depression on the Interrelation Between Brain Energy Metabolism and Ion Homeostasis In-Vivö. During that time, they published 28 articles on the CSD subject.

Inhalt

Aim of the book.- Basic principles and technology of nadh and multiparametric monitoring used in studying cortical spreading depression (csd).- Single point and multisite monitoring of brain nadh fluorescence under csd.- Sequence of physiological responses recorded during induced csd event.- Spontaneous development of csd related to brain pathophysiological conditions.- The effects of brain metabolic and other perturbations on the responses to induced csd.- Effects of pharmacological agents on csd.- Clinical monitoring of csd in the human brain.- CSD and the lifenlight score (lls).- Discussion and conclusions.- Index. <p