The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application.

Zusammenfassung
Arms you with the advances in the battle against cancer. This title explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease.

Inhalt

The Molecular Basis of Cancer, 4e Mendelsohn, Howley, Israel, Gray, Thompson Part I: Carcinogenesis and Cancer Genetics 1. Cancer, A Genetic Disorder 2. Oncogenes and Signal Transduction 3. Tumor Suppressor Genes 4. Genomic Instability and DNA Repair 5. Epigenetics and Cancer 6. Infectious Agents and Cancer 7. Environmental Carcinogenesis 8. Animal Models: Flies, Fish and Yeast 9. Genetic Mouse Models of Cancer Part II: Cancer Biology 10. Cancer Stem Cells 11. Regulation of the Cell Cycle 12. Cell Growth 13. Cancer Cell Metabolism 14. Apoptosis, Autophagy and Necrosis 15. Cell Growth Arrest and Senescence 16. Stromal-Cancer Interactions in the Microenvironment 17. Hypoxia and Angiogenesis 18. Invasion and Metastasis 19. Inflammation and Cancer 20. Molecular Pathways and Systems Biology Part III: Molecular Pathology and Diagnostics 21. Biomarkers Assessing Risk of Cancer 22. Biomarkers for Detecting Cancer: Molecular Screening 23. Biomarkers for Predicting Response to Specific Therapy 24. The Technology of Analyzing Nucleic Acids 25. Imaging Cancer