Provides an engaging account of how genetic abnormalities, neurobiology and neuropsychology work in concert to manifest cognitive-behavioral dysfunction. The authors have woven the various molecular genetic, genomic, neurophysiological and neurobehavioral threads together into a cohesive fabric of human genes, brain, and behavior. The first section provides and introduction to neurobehavioral disorders and their phenotypes in order to investigate the pathway between genes and behavior. The second section covers autosomal disorders that produce neurobehavioral dysfunction including neurofibromatosis, Prader-Willi syndrome, and tuberous sclerosis among others. The final section considers X-linked disorders in which syndromal and nonsyndromal forms of XLMR are present. It includes the first comprehensive account of the genotype and phenotype in FRAXE, the other fragile X mutation.

Inhalt
1 Quality Assurance in Environmental Trace Analysis.- 1. The Quality Assurance Program.- 2. Quality Control Procedures in the Quality Assurance Program.- 3. Operation of a Quality Assurance Program.- References.- 2 Applications of HPLC to the Analysis of Polycyclic Aromatic Hydrocarbons in Environmental Samples.- 1. Introduction.- 2. Nomenclature, Structure, and Carcinogenicity.- 3. Origin and Formation in the Environment.- 4. Methods of Analysis for Polycyclic Hydrocarbons.- 5. HPLC Applications in PAH Analysis.- 6. Conclusions.- References.- 3 HPLC of Pesticide Residues in Environmental Samples.- 1. Introduction.- 2. Instrumentation and Methodology.- 3. Applications.- 4. Conclusions.- References.- 4 HPLC Determination of Surfactants and Related Compounds.- 1. Anionic Surfactants and Related Compounds.- 2. Nonionic Surfactants.- 3. Cationic and Amphoteric Surfactants and Related Compounds.- References.- 5 Trace Metal Analysis by High Performance Liquid Chromatography.- 1. Introduction.- 2. HPLCUltraviolet, Visible, and/or Fluorescence Detection of Metal Species.- 3. HPLCMass Spectrometric Detection of Metal Species.- 4. HPLCAtomic Absorption Spectroscopic Detection of Metal Species.- 5. HPLCAtomic Fluorescence Spectroscopic Detection of Metal Species.- 6. HPLCInductively Coupled or Direct-Current Plasma Emission Spectroscopic Detection of Metal Species.- 7. HPLCElectrochemical and Conductivity Detection of Metal Species.- 8. Ion ChromatographyConductivity Detection of Metal Species.- 9. Conclusions.- References.- 6 Anion Analysis by Ion Chromatography.- 1. Introduction.- 2. Separation Modes.- 3. Detection Modes.- 4. New Applications in Anion Ion Chromatography.- 5. Summary.- References.- 7 HPLC Sample Injection and Column Switching.- 1.HPLC Sample Injection Using Valves.- 2. HPLC Column Switching.- References.- 8 High Performance Liquid Chromatography as a Cleanup Technique.- 1. Introduction.- 2. Cleanup for Gas Chromatography (GC) with Electron Capture (EC) or Flame Detection.- 3. Cleanup for GCMass Spectrometry (MS).- 4. HPLCHPLC.- 5. Cleanup for Radioimmunoassay (RIA).- 6. Radioisotope Fractionation.- 7. Summary.- References.