Iron deficiency is ever-present among all populations throughout the world irrespective of race, culture, or ethnic background. Even with the latest advances in medicine, improved nutrition, and the ready availability of cheap oral iron, there is still no satisfactory explanation for the widespread occurrence of iron deficiency or for the absence of an effective treatment. Iron Deficiency and Overload: From Biology to Clinical Medicine is an important new text that provides a timely review of the latest science concerning iron metabolism as well as practical, data-driven options to manage at-risk populations with the best accepted therapeutic nutritional interventions. Chapter topics reflect the excitement in current theoretical development and laboratory activity in this area. The distinguished authors address their presentations to professionals and graduate students who need to be better informed about the concepts, methodologies, and current status of the field. Iron Deficiency and Overload: From Biology to Clinical Medicine is an essential text that presents a sampling of the major issues in iron research, from the most basic research level to human applications.

Includes public health concerns Examines behavioral effects Central nervous system disorders and treatment Includes supplementary material: sn.pub/extras

Inhalt
Iron Biochemistry and Metabolism.- The Cellular Physiology of Iron.- Regulation of Iron Absorption and Distribution.- The Role of Hepcidin in Iron Homeostasis.- Iron as Nutrient: Strategies for Iron Acquisition and Usage by Pathogenic Microorganisms.- Iron as a Drug and DrugDrug Interactions.- Iron Overload and Deficiency Pathologies.- Iron Deficiency and Excess in the Brain: Implications for Cognitive Impairment and Neurodegeneration.- Brain Iron Deposition in Aging and Disease: Role of HO-1.- Iron Deficiency and Neuropharmacology.- Peripheral Effects of Iron Deficiency.- Iron-Metabolism in Neurons of the Motor System of the Central Nervous System: Lessons from Iron Deficiency and Overloading Pathologies.- The Effects of Brain Iron Deficiency on Cognitive and Behavioral Aspects.- Stress, Immunology, and Cytokines.- Diagnostic and Clinical Aspects in CNS Disorders.- MRI of Brain Iron and Neurodegenerative Diseases: A Potential Biomarker.- Alzheimer's Dementia.- Inherited Disorders of Brain Iron Homeostasis.- Public Health Issues.- Iron and Heart Disease: A Review of the Epidemiologic Data.- Global Concept of Iron Deficiency.- Nutritional Iron Deficiency in Early Childhood.- Iron and Women's Health.