Pathophysiology of Heart Disease

It is indeed ironical that in the absence of a complete knowledge of Pathophysiology, clinical cardiologists are left with no choice but to do the best they can to help the patient with the armamentarium of drugs at their disposal. But nothing could be further from truth than to treat the diagnosed end point of a disease process without a full understanding of its patho physiology. This point was eloquently made by Dr. Arnold Katz in his Presidential Address (Chapter 1) at the 8th Annual Meeting of the American Section of the International Society for Heart Research held in Winnipeg, Canada, July 8-11, 1986. This volume represents a part of the scientific proceedings of this Meeting. From a reading of this treatise it will become evident that discoveries of newer scientific facts as well as a better understanding of pathophysiology are continuously influencing/ improving our therapeutic approaches in modern medicine. In this book, latest biochemical, physiological and pharmacological findings on different experimental models such as Myocaridal hypertrophy, Hypertension and heart failure, Diabetes, Cardio myopathies and Cardiac function in shock are described by internationally recognised experts. Hopefully information presented here will provide another building block to the edifice of Science of Cardiology which we all are trying to create. Acknowledgements We are grateful to the following Agencies and Foundations for their generous financial support of the Symposium, which formed the basis of this book. A. Major Contributors: 1. Manitoba Heart Foundation 2. Sterling-Winthrop Research Institute 3. Squibb Canada, Inc.

Inhalt
A. Presidential Address.- 1. Role of the Basic Sciences in the Practice of Cardiology.- B. Myocardial Hypertrophy.- 2. Physiological and Pathological Hypertrophy.- 3. Potential Role of Catecholamines in the Production of Physiological and Pathological Hypertrophy.- 4. Role of Thyroid Hormone in the Regulation of Cardiac Hypertrophy.- 5. Oxygen Sources and Sinks in Myocardial Hypertrophy.- 6. Stretch, A Common Denominator in Muscle Growth.- 7. The Quantity and Rate of Calcium Uptake in Normal and Hypertrophied Hearts.- C. Hypertension and Heart Failure.- 8. Implications of Atrial Natriuretic Factor (ANF) in the Pathogenesis of Experimental and Human Hypertension.- 9. Plasma Concentration of Atrial Natriuretic Factor in Congestive Heart Failure.- 10. Mechanisms of Vasoconstriction in Hypertension and Chronic Congestive Heart Failure.- 11. Possible Adverse Effects of Catecholamines in Congestive Heart Failure: A Rationale for Beta-Blocker Therapy.- D. Heart Disease in Diabetes.- 12. Cardiac Dysfunction in the Diabetic Heart.- 13. The Association of Membrane Alterations with Heart Dysfunction During Experimental Diabetes Mellitus.- 14. Abnormalities in Contractile Proteins in Myocardium from Chronic Diabetic Animals.- 15. Energy Metabolism in Diabetic Heart.- 16. Myocardial Substrate Utilization in Acute and Chronic, and in Latent and Severe Diabetes.- 17. Triacylglycerol Lipase Activities and Rates of Endogenous Lipolysis in Myocardial Cells from Diabetic Rat Hearts.- 18. Involvement of Catecholamines in the Development of Diabetic Cardiomyopathy.- E. Cardiomyopathies.- 19. Ultrastructural Abnormalities in Different Types of Cardiomyopathies.- 20. Alcoholic Cardiomyopathy: Studies of Protein Metabolism.- 21. Pathophysiology of Anthracycline-Induced Cardiomyopathy.- 22. Effects of a Chronic Adriamycin Treatment of Rats on Myocardial Lipid Histochemistry.- 23. The Hypothyroid State in Cardiomyopathic Hamsters.- F. Cardiac Function in Shock.- 24. Myocardial Failure and Excitation-Contraction Uncoupling During the Course of Canine Endotoxin and Hemorrhagic Shock.- 25. Heart Function and Metabolism in Shock During Sepsis and Endotoxemia.- 26. Role of Leukotrienes in the Pathogenesis of Shook and Trauma.- 27. Intrinsic Cardiodynamic Response to Thermal Injury.