Integument and Mammary Glands

The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmon ize toxicologic testing, to advance a more uniform inter pretation of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scien tists. The Monographs on the Pathology of Laboratory Ani mals are designed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others concerned with evaluating toxicity and carcinogen icity studies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our ex pectations that understanding and cooperation will be im proved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on the integumentary system, is the seventh volume of a set prepared under the sponsorship of the International Life Sciences Institute (ILSI).

Klappentext

This volume is one of a set of concise, well-illustrated and authoritative studies of natural and experimental lesions of laboratory animals (rat, mouse and hamster) arranged by organ systems. The volume BIntegument and Mammary Glands/B includes not only neoplastic but also non-neoplastic lesions as well as the effects of toxins. It proposes a standard, international nomenclature that is particularly important for the documentation and evaluation of pathologic data produced in safety studies. Emphasis is also given to precise differential diagnostic criteria. Useful data on pathogenesis, etiology, biologic behavior, frequency in different strains and under varying laboratory conditions are given. The significance of each lesion is considered and comparisons are made with other species including man. References to the world literature have been selected to permit access to the critically important publications on each subject. This volume, as others in the Monographs on the Pathology of Laboratory Animals series, will contribute to improved world-wide communication among scientists, industries and governments on the safety of foods, drugs and chemicals subjected to tests in animals.

Inhalt
The Integument.- General.- New Approaches and Diagnostic Techniques in Dermatopathology.- Neoplasms.- Squamous Cell Papilloma, Skin, Rat.- Squamous Cell Papilloma, Skin, Mouse.- Squamous Cell Carcinoma, Skin, Rat.- Squamous Cell Carcinoma, Skin, Mouse.- Squamous Cell Carcinoma Arising in Induced Papilloma, Skin, Mouse.- Basal Cell Carcinoma, Skin, Rat.- Basal Cell Tumor, Skin, Mouse.- Trichoepithelioma, Skin, Rat.- Melanocytic Tumors, Skin, Mouse.- Melanocytic Tumors, Skin, Hamster.- Melanocytic Tumors, Rat.- Fibroma, Dermis and Subcutis, Rat.- Fibrosarcoma, Dermis and Subcutis, Rat.- Fibroma, Dermis and Subcutis, Mouse (Especially B6C3F1 Mouse).- Fibrosarcoma, Dermis and Subcutis, Mouse.- Lipoma, Subcutis, Rat.- Liposarcoma, Subcutis, Rat.- Fibrous Histiocytoma, Malignant, Subcutis, Rat.- Mast Cell Tumor, Skin, Mouse.- Clitoral Gland Tumors, Mouse.- Hibernoma, Rat.- Nonneoplastic Lesions.- Epidermal Inclusion Cyst, Skin, Rat.- Alopecia, Rat and Mouse.- Cutaneous Sensitization, Experimental, Mouse, Hamster, Rat.- Steatitis, Subcutaneous and Generalized, Rat.- Follicular Hyperkeratosis, Induced, Rabbit Ear.- Viral Infections.- Mousepox, Skin, Mouse.- Papillomavirus Infection, Skin, Mouse.- Inherited Conditions.- Obese Mutant Mice: Obese (ob) and Diabetes (db).- The Skin of the Rhino Mouse.- Hairless Mouse, HRS/J hr/hr.- Skin of the Pupoid Fetus (pf/pf) Mutant Mouse.- Skin of the Repeated Epilation (Er/Er) Mutant Mouse.- The Tight Skin (TSK) Mouse.- Asebia, a Mutation Affecting Sebaceous Glands, Mouse.- Ichthyosis, Inherited, Skin, Mouse (ic/ic).- The Mammary Gland.- Structure and Function.- Morphology and Development of the Rat Mammary Gland.- Endocrine Influences on the Mammary Gland.- Histologic/Immunocytochemical Markers, Mammary Gland, Rat.- Neoplasms.- Classification of Neoplastic and Nonneoplastic Lesions of the Rat Mammary Gland.- Factors That Modulate Chemical Carcinogenesis in the Mammary Gland of the Female Rat.- Markers in Chemically Induced Tumors, Mammary Gland, Rat.- Adenoacanthoma, Mammary Gland, Mouse.- Mixed Adenocarcinoma, Mammary Gland, Mouse.