IgE Receptor (Fc RI) Function in Mast Cells and Basophils

The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. Manipulating the function of this receptor is important for controlling the onset of allergic diseases. Written by leading scientists in the field, this book is the first comprehensive monograph to cover various aspects of FceRI structure, signal transduction and function. Thus, the book is valuable for researchers/students working on FceRI and on other receptors. In addition, clinicians who are concerned with broadening their knowledge of the FceRI role in allergic diseases will find this book useful.

Inhalt

1. Fc?RI: Perspective.- 2. The Structural Basis of the Interaction of IgE and Fc?RI.- 3. Fc?RI-Induced Protein Tyrosine Phosphorylation.- 4. Role of Phospholipases, Protein Kinases and Calcium in Fc?RI-Induced Secretion.- 5. Role of GTP-Binding Proteins in Fc?RI Signaling.- 6. Phosphorylation of Serines and Threonines in Fc?RI-Mediated Responses in Mast Cells.- 7. Protein Tyrosine Phosphatases in Signaling Through the Fc?RI on Mast Cells and Basophils.- 8. Regulation and Roles of the Membrane, Cytoskeletal and Adhesive Responses of RBL-2H3 Rat Tumor Mast Cells to Fc?RI Crosslinking.- 9. Fc?RI-Mediated Cell Degranulation, Proliferation and Adhesion.- 10. Signal Transduction Pathways Regulating Arachidonic Acid Metabolite Generation Following Fc?RI Aggregation.- 11. Fc?RI-Induced Cytokine Production and Gene Expression.- 12. Regulation of Fc?RI Function by Integrins and Other Molecules on Mast Cells and Basophils.- 13. Signal Transduction Issues in Studies of Human Basophils and Mast Cells.