Includes supplementary material: sn.pub/extras

Zusammenfassung

This book covers topics that range from fundamental studies of DNA replication, chromosomal and nuclear function through growth factor control of endocrine tumor initiation and progression. The basic and translational insights gained from Hormonal Control of Cell Cycle will be of interest to those studying the biology of endocrine tumors as well as those deriving novel therapeutic approaches for these benign and malignant disorders.

Inhalt
DNA Replication Origins, Development, and Cancer.- Getting In and Out of Mitosis.- Nuclear Receptors and Cyclins in Hormone Signaling.- A Novel Function for Cyclin E in Cell Cycle Progression.- IGF-I and the Regulation of Cell Cycle Progression in Smooth Muscle Cells.- Deciphering the Conundrum of Estrogen-driven Breast Cancer: Aurora Kinase Deregulation.- Androgen-mediated Control of the Cyclin D1-RB Axis: Implications for Prostate Cancer.- Pituitary Trophic Status as a Tumorigenic Determinant.- p27 Regulation by Estrogen and Src Signaling in Human Breast Cancer.- The Synergy of Two Ovarian Hormone-induced Enzymes in Human Mammary Carcinogenesis.- Steroid Receptors, Stem Cells and Proliferation in the Human Breast.- Estrogens, Cell Proliferation and Breast Cancer.