In mammals, a robust physiologic system acts to maintain relative constancy of weight. A key element of this system is leptin. The nature of this "brain-somatic" cross talk is as yet poorly understood, but it is likely to have important implications for the pathophysiology and treatment of obesity, diabetes and other metabolic disorders.

Includes supplementary material: sn.pub/extras

Inhalt
Interactions of Growth Hormone Secretagogues with Leptin-Sensitive Brain Networks.- Leptin and the Neural Circuit Regulating body Weight and Metabolism.- Role of the Growth Hormone Secretagogue Receptor in the Central Nervous System.- Regulation of Galanin-Like Peptide (GALP) in the Brain and Posterior Pituitary: A Review.- Ghrelin and the Growth Hormone Neuroendocrine Axis.- Adipose Tissues as Part of the Immune System: Role of Leptin and Cytokines.- Regulation of Body Weight Homeostasis During Pregnancy and Lactation.- Ghrelin: From GH Control to Feeding Behaviour and Sleep Regulatio.- Effect of Leptin on Fatless Mice.- Leptin, Growth and Reproduction.- An Emerging Role of Leptin in Clinical Psychiatry.- Genomic approach to common human obesity.- The Epigenetic Inheritance Hypothesis.