This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.

Offers new insights into the fascinating area of HIV latency and persistence from multiple perspectives and scientific directions Provides in-depth analyses of current concepts, paradigms and ideas that drive the HIV-1 cure agenda Identifies areas that require specific emphasis in future studies

Autorentext
Guido Silvestri

Emory University School of Medicine, Atlanta, GA 30329, USA

gsilves@emory.edu

Mathias Lichterfeld

The Brigham and Women's Hospital and the Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA

MLICHTERFELD@mgh.harvard.edu

Inhalt

Molecular Control of HIV and SIV Latency.- Assays to Measure Latency, Reservoirs and Reactivation.- The Antiviral Immune Response and its Impact on the HIV-1 Reservoir.- Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy.- SIV Latency in Macrophages in the CNS.- Mathematical models of HIV latency.- Residual Immune Activation and Latency.- Immune Interventions to Eliminate the HIV Reservoir.- Cell and Gene Therapy for HIV Cure.