This book now published in its fully updated second edition comprehensively summarizes the current state of knowledge on malignancies of the gastrointestinal tract and highlights the latest efforts in multimodality treatment options before and after surgery, important ongoing trials as well as future areas of investigation. Dedicated organ-based chapters evaluate current treatments and management and provide information on incidence, etiology and biological characteristics. The state of the art in the radiologic and endoscopic staging of gastrointestinal malignancies is described, and guidance is offered on the role of interventional radiology and interventional gastroenterology in the treatment of these challenging tumors. In addition, the book explores novel and evolving treatments, including Immunotherapy, personalized systemic therapy and minimally invasive surgical and radiology techniques, and addresses patient-reported outcomes and survivorship challenges. It will be of benefit to all surgeons, oncologists and other specialists who treat these malignancies, as well as to trainees looking to increase their understanding of the field.

Presents up to date clinical trials for gastrointestinal malignancies Discusses current and novel therapies for the various malignancies of the gastrointestinal tract Describes pathologic features and molecular risk factors for gastrointestinal malignancy

Autorentext

****Al B Benson III, MD, FACP, is a Professor of Medicine in the Division of Hematology/Oncology at Northwestern University Feinberg School of Medicine in Chicago, IL. He is also the Associate Director for Clinical Investigations and Chair of the Clinical Protocol Scientific Review and Monitoring System for the Robert H Lurie Comprehensive Cancer Center, a National Cancer Institute-designated Comprehensive Cancer Center, at Northwestern University. He is a recipient of the American Society of Clinical Oncology (ASCO) Statesman Award and has served on a number of committees. He is a member of the Task Force on Quality of Cancer Care, the Co-Chair of ASCO's Colorectal Cancer Guidelines Subcommittee, the Stage II Colon Cancer Guidelines Panel, and the Guidelines Panel for the use of Radiofrequency Ablation for Colorectal Cancer Hepatic Metastases. He is Chair of both the Eastern Cooperative Oncology Group Gastrointestinal and Data Monitoring Committees. In addition, he is a member of several medical societies, and is Past President of the Illinois Medical Oncology Society, and President for the Association of Community Cancer Centers, and past Chair of the Board of Directors of the National Comprehensive Cancer Network. Dr Benson is past President of the International Society of Gastrointestinal Oncology. He has authored numerous reports, reviews, and book chapters focusing on the topics of biologics, cancer therapy, and cancer prevention.

David Bentrem, MD, MSCI is the Surgery Service Chief at Jesse Brown VA Medical Center and a Professor of Surgery at Feinberg School of Medicine, Northwestern University.  Dr. Bentrem has a focused interest in GI oncology examine the role of the tumor microenvironment in pancreas and colon cancer.  In addition, his research also focuses on the development of quality measures in cancer surgery and served on committees with the Commissionon Cancer, the American College of Surgeons and the Society of Surgical Oncology in this area.

Inhalt

Environmental and Genetic Risk Factors for Gastric Cancer.- Pathologic Features of Esophageal and Gastric Malignancies.- Pathologic Features of Miscellaneous Foregut Malignancies.- Pancreatic Cancer.- Pathologic Features of Primary Pancreatic Malignancies.- Contemporary trials evaluating neoadjuvant therapy for resectable pancreatic cancer.- A NSQIP-Based Randomized Clinical Trial Evaluating Choice of Prophylactic Antibiotics for Pancreaticoduodenectomy.- Gallbladder Cancer.- Diagnosis and Management of Intrahepatic and Extrahepatic Cholangiocarcinoma.- Hepatocellular Carcinoma: Surgical Management and Evolving Therapies.- Locoregional Therapies for Primary and Secondary Hepatic Malignancies.- Pathologic Features of Primary Colon, Rectal and Anal Malignancies.- Hepatic artery infusion therapy for Metastatic Hepatic Malignancies.- Immunotherapy/ Immunology of Gastrointestinal Tumors.- Genetic Implications to Clinical Applications.