This is the first volume of a three-volume series on Frontiers of Longevity Science . The series unites global experts to map the rapidly expanding field of longevity medicine. Co-edited by David Barzilai, Max Rangeley, Regina R. Monaco, and David Wood, the series bridges molecular mechanisms, translational innovation, economics, and policy. Contributors from geroscience and the social sciences debate a central question: can we merely slow age-related diseases, or can the biology of aging itself be fundamentally changed?

Volume 1, The Biology of Life Extension , examines the root mechanisms of aging. From evolutionary theories to the cellular hallmarks driving degeneration, leading researchers explore cutting-edge strategies to intervene directly in the aging process. Topics include damage repair, organ replacement, genetic medicine, senotherapeutics, and cellular reprogramming. These chapters map the scientific foundation that could transform extended longevity from an aspiration into an engineered reality.

Discusses the economic, social, and political impacts of radical longevity Highlights revolutionary technologies for extending lifespan Offers new insights for scholars and professionals at international institutions such as the WHO

Autorentext

Max Rangeley runs a think tank founded by a member of Parliament in the UK and has served on the boards of other think tanks in London and Brussels. He has put an emphasis on the importance of emerging technologies, including organising and moderating the artificial intelligence roundtable discussions in the European Parliament. Max has authored and co-edited several books with Springer Nature, on central banking, trade, artificial intelligence, the future of money and the power of the mind in medicine among other topics. He studied at the London School of Economics, the University of Aberdeen, and HEC Paris.
Dr. David Barzilai is a longevity physician, thought leader in evidence-based best practices, and Founder and CEO of Barzilai Longevity Consulting. A Lecturer at Harvard Medical School, global speaker, and founding faculty member and Trustee of the Geneva College of Longevity Science, he holds an MD and PhD in health services research and is board-certified in lifestyle medicine. Through Agingdoc.com, he serves individuals, executives, and organizations in consulting and advisory roles, translating advances in longevity science into precise, personalized strategies that optimize healthspan and long-term performance.
Dr. Regina R. Monaco is a theoretical chemist with a PhD in chemistry and biochemistry from the University of Texas at Austin. She is a Senior Research Fellow at the City University of New York and a scientific consultant affiliated with the Courant Institute at New York University. She has held fellowships at NASA Ames Research Center, the Santa Fe Institute, the Max Planck Institute for Biophysical Chemistry, and the Aaron Diamond AIDS Research Center. Her research spans mechanistic and thermodynamic studies of biopolymers, including ras p21, p53, and small-molecule DNA interactions. Her current work focuses on information transfer in complex dynamical networks, with applications to biological and networked systems.
David W. Wood is a futurist and author of 12 books, including The Abolition of Aging , Vital Foresight , and The Singularity Principles . He chairs London Futurists, where he has organized over 350 public events on technoprogressive topics since 2008. David is the executive director of the LEV Foundation and was previously a pioneer in mobile computing, co-founding Symbian and serving as CTO of Accenture Mobility. He holds an M.A. in Mathematics from Cambridge University and completed postgraduate work in the History and Philosophy of Science. He also holds an honorary doctorate from the University of Westminster.

Inhalt

Part I. Theories of aging.- Chapter 1. The Strong Epigenetic Theory: Aging as a Suicide Program (Yuri Deigin).- Chapter 2. The Ultimate Cause of Aging (Michael Ringel).- Chapter 3. Can aging be a program? A critical evaluation of the evolutionary theories (Peter V. Lidsky).- Chapter 4. Hormones, Phenomics and the Aging Process (Steven A. Garan).- Chapter 5. Longevity and and the Perpetual Struggle Against Entropy (Max Rangeley).- Chapter 6. Natural pathways to radical longevity (Greg Fahy).- Part II. Hallmarks of aging and damage repair.- Chapter 7. Current Approaches to Repair of Aging Damage (Aubrey de Grey).- Chapter 8. Piece by Piece, then All at Once: The SENS Seven as More Direct Roadmap (Michael Rae).- Chapter 9. Replacement: The Most Near Term Path to Reversing Aging (Mark Hamalainen).- Chapter 10. Genetic Medicine for Aging (Matthew Scholz).- Chapter 11. Longevity through enhancing DNA repair (Christopher Bradley).- Chapter 12. The Aging Vasculature: Mechanisms of Degeneration and Paths to Rejuvenation (Matthew O'Connor).- Chapter 13. Senescent Cells and Senotherapeutics: Opportunities and Open Questions (Brennan D. Stadler).- Part III. Transformational biotechnologies.- Chapter 14. Mitochondrial Interventions for Resilience, Function, and Longevity (Andy Lee).- Chapter 15. Nuclear reprogramming and organs in a dish: A new personalized approach to healthy longevity (Vittorio Sebastiano).- Chapter 16. Stem cells, exosomes, and longevity (Yuta Lee).