The day it rained in Wepion ..... . The NATO Course on Regulation of Function and Growth of Eukaryo tic Cells by Intracellular Cyclic Nucleotides was organized in Wepion (Belgium) from September 23 to October 1, 1974, by L. Birn baumer (Chicago), B.L. Brown (London), R.W. Butcher (Worcester), J.E. Dumont (Brussels), M. Paiva (Brussels) and G. Van den Berghe (Louvain), under the benevolent and most efficient aegis of Dr. T. Kester (NATO, Brussels). The formula of the Course was inspired by the Gordon Con ference with its combination of a pleasant, friendly and easygoing atmosphere together with a solid and critical scientific diet offered in the morning and evening, the afternoon being free. For these reasons, the meeting was located in a pleasant motel in beautiful surroundings by the side of the Meuse river, in the country, but close to the town of Narnur. Everything, absolutely everything, from swimming to tennis, to horse riding,was available to make the afternoons agreeable and to facilitate social contacts.

Inhalt
Cell Fractionation by Centrifugation Methods.- Binding of Ligands to Receptors: Theory.- On the Modes of Regulation of Intracellular Cyclic AMP: Desensitization of Adenylyl Cyclases to Hormonal Stimulation and Compartmentalization of Cyclic AMP.- The Interaction of Glucagon with Isolated Plasma Membranes of Rat Livers: The Relevancy of Measuring Binding Sites.- Hormone Binding To Receptors: Vasopressin.- Effects of Choleragen and Fluoride on Adenylate Cyclase.- Stimulation of Adenylate Cyclase in the Thyroid.- Guanylate Cyclase.- Regulation of Cyclic AMP Phosphodiesterase Activity.- Theoretical Simulation of the cAMP System.- Control of Metabolic Processes by cAMP-Dependent Protein Phosphorylation.- Cyclic AMP and Cyclic GMP Binding in Tissues.- The Assay of Cyclic AMP in Biological Material.- Determination of Cyclic GMP in Biological Material.- Methods for the Study of Cyclic AMP Metabolism in Intact Cells.- The Actions of Nucleotides on Adenylyl Cyclase Systems.- Cyclic AMP Metabolism of Some Fibroblastic and Epithelial Cells in Vitro.- Metabolism of Cyclic GMP in Vascular Smooth Muscle, Leukocytes, and Lung.- Cyclic Nucleotide Analogues.- Microtubule Morphology.- Cyclic AMP and Microtubules.- Prostaglandins and Cyclic Nucleotides.- Re-Examination of the Role of Cyclic AMP in the Actions of Glucagon and Epinephrine.- The Role of Cyclic AMP in the Regulation of Glycogen Metabolism.- Cyclic AMP and Pyruvate Dehydrogenase.- Cyclic AMP and Protein Synthesis.- Cyclic AMP and the Control of Lypolysis in Fat Cells of the Rat.- Studies on the Permissive Effect of the Thyroid on Fat Cells.- Cyclic Nucleotides, Calcium and Ion Transport.- Insulin Secretion The Role and Mode of Action of Cyclic AMP.- Effects of Cyclic AMP on B-Cell Function.- Role of Cyclic Nucleotides inthe Anterior Pituitary Gland.- Mechanism of LH and FSH Action on the Testis.- Possible Roles of Cyclic Nucleotides in the Regulation of Smooth Muscle Tonus.- The Regulation of Thyroid Cell Metabolism.- Behavior of Cultured Fibroblasts, the Cell Surface and Cyclic AMP.- Chromatin Structure and the Role of Histone Phosphorylation in the Cell Cycle.- Cyclic Nucleotides and Cell Adhesion.- Cyclic AMP and Cancer.- Cyclic Nucleotides and Cell Growth.- Cyclic AMP and Myoblast Differentiation.- Diseases Involving Cyclic AMP.