Comprehensively reviews database establishment, computational tools, experimental strategies, and biochemistry/crystallographic studies of metalloenzymes and their drug discovery applications.

Autorentext

Guo-Bo Li is Professor in the Department of Medicinal Chemistry at Sichuan University, China. His research group now focuses on development of new computational tools, new data resources and new web servers to assist basic science and drug discovery research particularly targeting metalloenzymes, and development of new chemical probes, new hits/leads or drug candidates to exploit metalloenzyme biological/pathological roles and therapeutical potentials.

Inhalt
Metalloenzyme Informatics and Drug Design
Metal-Binding Pharmacophores in Metalloenzyme Drug Discovery
Modelling Metalloenzyme Catalytic Mechanisms by QM/MM Calculations
Experimental Strategies in Metalloenzyme Mechanism Study and Drug Discovery
Targeting Metalloenzymes by Metallo-Drugs
Targeting Metallo-ß-Lactamases to Combat Antibiotic Resistance
Targeting Disease-Linked Metalloenzymes Involved in RNA metabolism
Cyclic Nucleotide Phosphodiesterases: Important Therapeutic Targets
HDAC, A Rising Star in Cancer Therapy
Drug Discovery Targeting Viral Metalloenzymes
Drug Discovery Targeting Carbonic Anhydrases
Targeting Autotaxin for Therapeutic Intervention
Targeting ENPP1 for Therapeutic Intervention
Drug Discovery Targeting Oxygen-Sensing Hypoxia-Inducible Factor Prolyl Hydroxylases
Hijacking Histone Demethylase KDM5B for Novel Therapeutics
Advances and Future Directions in Small-Molecule LpxC Inhibitors Targeting Gram-Negative Bacteria
Substrate and Inhibitor Discovery of Human Glutaminyl Cyclases
Drug Discovery Targeting Tryptophan/Indoleamine 2,3-Dioxygenase