DNA Damage and Repair

Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.

Zusammenfassung
". . .serves as a comprehensive introduction to the eukaryotic repair field. The book will be of particular value to researchers who are newly entering the field, especially molecular biologists who wish to gain a broader historical, biological and medical perspective. . .this book was in high demand by my laboratory as soon as the review copy arrived. By this test, it will be a worthwhile addition to the personal library of investigators with research interests in the area of DNA repair."-The Quarterly review of Biology

Inhalt
1 Overview.- 2 DNA Photolyases.- 3 Cellular Responses to Methylation Damage.- 4 Exogenous Carcinogen-DNA Adducts and Their Repair in Mammalian Cells.- 5 Nature of Lesions Formed by Ionizing Radiation.- 6 Mammalian Enzymes for Preventing Mutations Caused by Oxidation of Guanine Nucleotides.- 7 Biochemistry of Mammalian DNA Mismatch Repair.- 8 Short Patch Mismatch Repair in Mammalian Cells.- 9 Role of HMG and Other Proteins in Recognition of Cisplatin DNA Damage.- 10 TFIIH: A Transcription Factor Involved in DNA Repair and Cell-Cycle Regulation.- 11 DNA Polymerase Involvement in DNA Repair.- 12 Cellular Functions of Mammalian DNA Ligases.- 13 Modulations in Chromatin Structure During DNA Damage Formation and DNA Repair.- 14 Transcriptional Responses to Damage Created by Ionizing Radiation: Molecular Sensors.- 15 Posttranslational Mechanisms Leading to Mammalian Gene Activation in Response to Genotoxic Stress.- 16 Mechanisms for DNA Double-Strand Break Repair in Eukaryotes.- 17 Mutant Rodent Cells Defective in DNA Double-Strand Break Repair.- 18 Nucleotide Excision Repair: Its Relation to Human Disease.- 19 Cellular Responses to DNA Damage and the Human Chromosome Instability Syndromes.- 20 Genetics of Mismatch Repair, Microsatellite Instability, and Cancer.- 21 Mammalian Cell-Cycle Responses to DNA-Damaging Agents.- 22 Poly(ADP-Ribose) Polymerase in Response to DNA Damage.- 23 DNA Topoisomerases in DNA Repair and DNA Damage Tolerance.- 24 Molecular Approaches for Detecting DNA Damage.- 25 Radiation-Induced Damage and the Formation of Chromosomal Aberrations.- 26 Whole Organism Responses to DNA Damage: Modulation by Cytokines of Damage Induced by Ionizing Radiation.- 27 DNA Damage and Repair in the Clinic.