Derek G. Waller, BSc, DM, MBBS, FRCP, Consultant Cardiovascular Physician, Southampton General Hospital; Senior Lecturer in Medicine and Clinical Pharmacology, University of Southampton, Southampton, UK

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Medical Pharmacology & Therapeutics provides all the information medical and healthcare students need throughout their degree programme and beyond, including for professional qualifications such as the PSA. This all-round textbook covers basic pharmacology through to drug prescribing in clinical contexts, covering the pathogenic mechanisms of disease; drug actions, side effects, and the therapeutic principles of drug use. It takes a helpful systems-based approach that orders information according to body systems and disease areas, rather than by drug class. Now in its sixth edition, the book has been fully updated to include latest scientific understanding of drug action and administration and current best practice in prescribing medications, informed by the latest national guidelines. A clinical focus throughout - suitable for medical, nursing and other healthcare students throughout their training Thorough update of clinically-relevant medicines to ensure best practice Information aligned with the British National Formulary (BNF), NICE guidelines and relevant professional benchmarks Comprehensive drug compendia allow all drugs to be identified and placed within their respective classes Extensive self-assessment questions to support learning and revision New to this edition Expanded discussion of the pathophysiology and management of shock Revised discussion of the management of chronic pain Consideration of treatment of Covid-19 Expanded discussion of the pathophysiology and management of shock Revised discussion of the management of chronic pain Consideration of treatment of Covid-19

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Preface

Drug Dosage and Nomenclature

SECTION 1 GENERAL PRINCIPLES

Principles of Pharmacology and Mechanisms of Drug Action
Pharmacokinetics
Drug Discovery, Safety and Efficacy
Neurotransmission and the Peripheral Autonomic Nervous System

SECTION 2 THE CARDIOVASCULAR SYSTEM

Ischaemic Heart Disease
Systemic and Pulmonary Hypertension
Heart Failure and Shock
Cardiac Arrhythmias
Cerebrovascular Disease and Dementia
Peripheral Artery Disease
Haemostasis

SECTION 3 THE RESPIRATORY SYSTEM

Asthma and Chronic Obstructive Pulmonary Disease
Respiratory Disorders: Cough, Respiratory Stimulants, Cystic Fibrosis, Idiopathic Pulmonary Fibrosis and Neonatal Respiratory Distress Syndrome

SECTION 4 THE RENAL SYSTEM

Diuretics
Disorders of Micturition
Erectile Dysfunction

SECTION 5 THE NERVOUS SYSTEM

General Anaesthetics
Local Anaesthetics
Opioid Analgesics and the Management of Pain
Anxiety, Obsessive-Compulsive Disorder and Insomnia
Schizophrenia and Bipolar Disorder
Depression, Attention Deficit Hyperactivity Disorder and Narcolepsy
Seizures and Epilepsy
Extrapyramidal Movement Disorders and Spasticity
Other Neurological Disorders: Multiple Sclerosis, Motor Neuron Disease and Guillain-Barré

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