This reference provides detailed coverage of dendritic spines, the fascinating neuronal components that modulate synaptic transmission, development, strength, and plasticity and are involved in the function of multiple areas of the nervous system. The density, shape, and function of spines may indicate the cellular connectivity and synaptic plasticity in normal and pathological conditions. This field has undergone dramatic advances in terms of techniques and experimental findings from in vitro to in vivo data, from animal models to human neurons, and computational models using artificial intelligence. To address these cutting-edge findings, the book provides state-of-the-art, comprehensive coverage with chapters written by the leading international researchers in the field. The authors consider the multiple implications for the study of dendritic spines with broad implications in the neurosciences and related areas.

Explores dendritic spines, key elements in the normal functioning of the brain and in neuropathologic conditions Provides state-of-the-art knowledge on this exciting and progressing area of neuroscience research Presents chapters from international leaders in the field of dendritic spines

Autorentext

Alberto A. Rasia-Filho, MD, PhD, is Professor, Department of Basic Sciences/Physiology and Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre, and Graduate Program in Neuroscience, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Maria Elisa Calcagnotto, MD, PhD, is Professor, Department of Biochemistry, Graduate Program in Biochemistry, Graduate Program in Neuroscience, and Graduate Program in Psychiatry and Behavioral Science, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

Oliver von Bohlen und Halbach, PhD, is Professor, Institut für Anatomie und Zellbiologie, Universitätsmedizin Greifswald, Greifswald, Germany

Inhalt
Chapter 1: Introduction: What are dendritic spines?.- Chapter 2: Techniques to render dendritic spines visible in the microscope.- Chapter 3: Electrophysiology of dendritic spines: information processing, dynamic compartmentalization and synaptic plasticity.- Chapter 4: Dendritic spines, synaptogenesis and synaptic pruning for the developmental organization of brain circuits.- Chapter 5: Neurotrophic factors and dendritic spines.- Chapter 6: Glial cell modulation of dendritic spine structure and synaptic function.- Chapter 7: Dendritic spines in learning and memory: from first discoveries to current insights.- Chapter 8: Steroid hormone interaction with dendritic spines: implications for neuropsychiatric disease.- Chapter 9: Morphological features of human dendritic spines.