This new edition provides comprehensive coverage of the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic fundamental principles as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. New topics include a detailed discussion of cells found within the nervous system, an extensive listing of congenital disorders of glycosylation of both proteins and lipids, the roles of glycans in neuronal axon growth/guidance and voltage-gated channels, the role of intra-lysosomal luminal vesicles in lysosomal storage disorders, and, in the time of the COVID-19 pandemic, the role of carbohydrates in infection by SARS-CoV-2. The breadth and depth of topics covered make this an essential reference for those new to the field as well as for more experienced investigators.

Provides an important reference on core topics and recent developments in an emerging field of neuroscience Presents authoritative coverage from authors and contributors who are the leaders in the field Updates a first-edition reference that established itself as the definitive work in the field

Autorentext

Cara-Lynne Schengrund, PhD, is Professor Emeritus, Department of Biochemistry and Molecular Biology, Penn State University, Hershey, Pennsylvania Robert K. Yu, PhD, Med ScD, was Professor, Department of Neuroscience and Regenerative Medicine, and GRA Eminent Scholar in Molecular and Cellular Neurobiology, Medical College of Georgia at Augusta University, Augusta, Georgia

Inhalt

1. Introduction to the complexity of cell surface and tissue matrix glycoconjugates..- 2. Introduction to cells comprising the nervous system..- 3. Synthesis.- processing.- and function of N-glycans in N-glycoproteins..- 4. Synthesis of O-linked glycoconjugates in the nervous system..- 5. Chemistry and function of glycosaminoglycans in the nervous system..- 6. Use of glycan-targeted antibodies/lectins to study the expression/function of glycosyltransferases in the nervous system..- 7. Capillary electrophoresis and mass spectrometry-based glycosylation analysis in glycomics and glycoproteomics..- 8. Structural analysis of oligosaccharides and glycoconjugates using NMR..- 9. Glycolipid and glycoprotein expression during neural development..- 10. Gangliosides and cell surface ganglioside glycohydrolases in the nervous system (request them to include gal-cer and sulfatide)..- 11. Role of myelin-associated glycoproteins in the peripheral nervous system..- 12. Glycosignaling: a general review..- 13. Glycosphingolipids in the regulation of the nervous system..- 14. O-GlcNAcylation of neuronal proteins: Roles in neuronal functions and in neurodegeneration..- 15. Glycoconjugates in nuclear membranes..- 16. N-glycosylation in regulation of the nervous system..- 17. Role of carbohydrates in the interaction of pathogens with neural cells..- 18. Glycoconjugate changes in aging and age-related diseases..- 19. Gangliosides and glycolipids in neurodegenerative disorders..- 20. Inborn errors of glycosphingolipid catabolism and potential treatment..- 21. Neurological aspects of human glycosylation disorders..- 22. Glycoconjugates and neural tumors..- 23. Galectins and neuroinflammation ..- 24. Glycoconjugates and neuroimmunological diseases..- 25. Targeting nanoparticle drug carriers to the brain..- 26. Use of quantum dots to treat inherited lysosomal storage diseases..- 27. MALDI-FTICR MS imaging of nervous system glycoconjugates.