Embryoimplantationisaremarkableandcomplexprocess. Approachesde velopedfromthefieldsofcellanddevelopmentalbiology,immunology, andmolecularbiologyhavegreatlyenhancedourabilitytostudythe sharedaswellasuniquefeaturesofembryo-uterineinteractions. Impres siveandcriticalgroundworkhasbeenlaidbyalargeanddedicatedarray ofendocrinologists,reproductivebiologists,andanatomists. Thesestudies havesetthestagetoutilizesensitiveandsophisticatedtechniquestode tectandmodulateproteinandgeneexpression. Justasthesymbiosisofmother andfetusiscriticalforthemaintenanceofpregnancy,soisthesynergyamong investigatorsfrommanydisciplines,bothinbasicandclinicalarenas,keyto unravelingthemysteriesofimplantationandplacentation. Alargegroupof contributorsinthisfieldhadtheopportunitytomeetanddiscussthestateof thisartwiththesupportofSeronoSymposiaUSA,Inc. Whileitisneverpos sibletobringtogethereveryonewhohasplayedanimportantrole,itwas, nonetheless,bothexcitingandgratifyingtohavesomanycolleaguestogether forthisevent. Inthechaptersthatfollow,thehighlightsofthismeetingarepresented assummarizedbytheindividualpresentersofsevendifferentsessions. The topichasbeenconsideredfromthebroadsocialandethicalimplications ofmoderninvitrofertilizationandassistedreproductivetechnologiesto detailedmolecularcontrolsovereventsthatoccurduringembryonicdevel opment,uterinepreparationforimplantation,andplacentalorganogenesis. Thesechaptersdemonstratethesignificantandrapidprogressbeingmade inthisfieldofbiologyandmedicine. Atthesametime,theyshowthat muchmoreneedstobedonetounderstandandfullyappreciatethispro cess. Lessonslearnedfromthiseffortcanbeexpectedtocontinuetopro videinsightsintoother,relatedfields. Ofthemanycontributorstoour understandingoftheprocessofimplantation,nonehavehadalargerim pactthanourcolleague,AllenEnders. Dr. Endershasplayedaparamount roleindevelopingthebasicunderstandingofthecellbiologicalprocesses vii VIII Preface underlyingimplantationandplacentationinmanyspecies,includinghu mans. Hecontinuestocontributeandguidethoughtintheseareas. The participantsofthissymposiumrecognizedDr. Enders'impressivecontribu tionsbyholdingthiseventinhishonor. DANIELD. CARSON Contents Preface vii Contributors xiii PartI. Development and Future ofHuman In Vitro Fertilization and Embryo Implantation I. ImplantationintheHumanasViewedbyCanonLaw, CivilLaw,andNaturalReason 3 HOWARDW. JONES, JR. , RICHARDA. MCCORMICK, AND SUSAN L. CROCKIN 2. TheImpactofMaternalAgeandOvarianAge onImplantationEfficiency. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 STEVEN SPANDORFER AND ZEV ROSENWAKS Part II. CellularAspects ofImplantation 3. VascularInvasionDuringImplantationandPlacentation 23 ALLEN C. ENDERS AND THOMASN. BLANKENSHIP 4. OxygenRegulatesHumanCytotrophoblastProliferation, Differentiation,andInvasion:Implicationsfor EndovascularInvasioninNormalPregnancy andPreeclampsia 39 OLGA GENBACEV,YAN ZHOU, MICHAEL T. McMASTER, JOHNW. LUDLOW, CAROLINEH. DAMSKY, AND SUSAN1. FISHER 5. Embryo-MaternalInteractionsafterDiapause inaMarsupial 54 MARILYNB. RENFREE AND GEOFFREY SHAW IX x Contents 6. CellularInteractionsandtheCysteineProteinases intheProcessofMouseImplantation 67 BRUCE BABIARZ, SUZANNE AFONSO, ANDLINDA ROMAGNANO Part III. HormonalRegulation 7. NovelSteroid-RegulatedMarkersofImplantation 83 INDRANIC. BAGCHI 8. MolecularSignalinginImplantation 92 SANJOYK. DAS, BIBHASHC. PARIA, AND SUDHANSU K. DEY 9. IdentificationofProgesterone-RegulatedGenes intheUterus 107 CINDEER. FUNK, BERTW. O'MALLEY, AND FRANCESCO1. DEMAYO PartIV. MolecularMarkersofReceptivity 10. MucinsProvideaBarriertoEmbryoImplantation 123 MARYM. DESOUZA, GULNARA. SURVEYOR, XINHUI ZHOU, JoANNE JULIAN, ANDDANIELD. CARSON II. PotentialInvolvementofTrophinin,Bystin, andTastininEmbryoImplantation 132 MICHIKON. FUKUDA, DAITA NADANO,NAO SUZUKJ, AND JUN NAKAYAMA 12. OsteopontininHumanEndometrium: ARoleinEndometrialReceptivityand EmbryoImplantation? 141 CHRISTOS COUTIFARJS,AKINYI

Klappentext

This volume contains the proceedings of the International Symposium on Embryo Implantation: Molecular, Cellular and Clinical Aspects, held from October 3-6, 1997 in Newport Beach, California. Internationally recognized experts discuss the development and future of human in vitro fertilization and embryo implantation, the cellular aspects of implantation, hormonal regulation, molecular markers of receptivity, trophoblast factors, primate models and animal studies, and transcriptional regulation of maternal-fetal recognition.

Inhalt
I. Development and Future of Human In Vitro Fertilization and Embryo Implantation.- 1. Implantation in the Human as Viewed by Canon Law, Civil Law, and Natural Reason.- 2. The Impact of Maternal Age and Ovarian Age on Implantation Efficiency.- II. Cellular Aspects of Implantation.- 3. Vascular Invasion During Implantation and Placentation.- 4. Oxygen Regulates Human Cytotrophoblast Proliferation, Differentiation, and Invasion: Implications for Endovascular Invasion in Normal Pregnancy and Preeclampsia.- 5. EmbryoMaternal Interactions after Diapause in a Marsupial.- 6. Cellular Interactions and the Cysteine Proteinases in the Process of Mouse Implantation.- III. Hormonal Regulation.- 7. Novel Steroid-Regulated Markers of Implantation.- 8. Molecular Signaling in Implantation.- 9. Identification of Progesterone-Regulated Genes in the Uterus.- IV. Molecular Markers of Receptivity.- 10. Mucins Provide a Barrier to Embryo Implantation.- 11. Potential Involvement of Trophinin, Bystin, and Tastin in Embryo Implantation.- 12. Osteopontin in Human Endometrium: A Role in Endometrial Receptivity and Embryo Implantation?.- V. Trophoblast Factors.- 13. The Rabbit as a Model for Implantation: In Vivo and In Vitro Studies.- 14. Regulation of Trophoblast Endocrine Function: The Placenta Does Its Own Thing Transcriptionally.- 15. Transcription Factors Regulating the Differentiation of the Trophoblast Cell Lineage.- VI. Primate Models and Human Studies.- 16. Hormonal Regulation of Endometrial Gene Expression in the Rhesus Monkey.- 17. EmbryoMaternal Dialogue in the Baboon (Papio Anubis).- 18. Integrins and Uterine Receptivity.- 19. Keratinocyte Growth Factor in the Nonhuman Primate Endometrium: Regulation and Action.- 20. Molecular Lesions in Infertility.- VII. TranscriptionalRegulation of FetalMaternal Recognition.- 21. The Role of Abdominal B (AbdB) Hoxa Genes During Implantation.- 22. Possible Role of the Transcription Factor Oct-3/4 in Control of Human Chorionic Gonadotropin Expression.- 23. Molecular Mechanisms Regulating Uterine Decidualization and Implantation: CellCell and CellExtracellular Matrix Interactions.- 24. Regulation of Hormone Receptor Gene Expression in Endometrium.- Author Index.