A comprehensive volume updating the latest research and clinical results using a new treatment modality for cancer. Advances in the field have been rapid; this is the only publication with such complete information.

Inhalt
The Development of Chemotherapy Drugs as Radiosensitizers: an Overview.- Section I Principles of Infusion Chemotherapy.- 1. Experimental Rationale for Continuous Infusion Chemotherapy.- 2. Combination Chemotherapy by Infusion in Hematological Malignancies.- 3. Combination Chemotherapy by Infusion in Solid Tumors.- 4. Admixtures of Chemotherapy Agents by Continuous Infusion.- 5. Time-Specified Delivery of Chemotherapy by Implantable Programmable Pumps - Preliminary Data on 5-Fluoro-2?-deoxyuridine.- 6. Advances in the Technology of Continuous Infusion.- Section II Radiosensitization and Radioprotection.- 7. Hypoxic Cell Sensitizers.- 8. Glutathione, a Determinant of Response to Cancer Treatment.- 9. Radiosensitization of Nonhypoxic Cells by Halogenated Pyrimidines.- 10 Perfluorocarbon Emulsion and Oxygen with Concomitant Radiation Therapy in Primary High Grade Brain Tumors.- 11. Chemo- and Radioprotection: Clinical Trials Combining WR-2721 with Cisplatin and Cyclophosphamide.- 12. Biological Modifiers' Potential for Radioprotection.- Section III 5-Fluorouracil Radiopotentiation and Its Modulation by Other Agents.- 13. Theoretical Basis and Clinical Applications of 5-Fluorouracil as a Radiosensitizer - an Overview.- 14. Efficacy of 5-Fluorouracil by Continuous Infusion as a Radiopotentiator - Anal and Rectal Carcinoma.- 15. Hepatic Metastases from Gastrointestinal Malignancies and Hepatocellular Carcinoma.- 16. The Use of Infusional 5-Fluorouracil, Mitomycin C, and Radiation as the Primary Management of Esophageal Cancer.- 17. Concomitant Radiation and 5-Fluorouracil for Head and Neck Cancer.- 18. Continuous Intravenous 5-Fluorouracil with Hydroxyurea and Concomitant Radiotherapy for Advanced Head and Neck Cancer.- 19. Treatment of Advanced Carcinoma of the Bladderwith Concomitant 5-Fluorouracil Infusion and Radiation.- 20. Combined 5-Fluorouracil and Irradiation for the Treatment of Invasive Bladder Cancer.- 21 Protracted (Continuous 5-Fluorouracil) Infusion with Concomitant Radiation Therapy: Indications and Results.- Section IV Radiopotentiation by Cisplatin in Continuous Infusion.- 22. Radiopotentiation in a Murine Tumor (MTG-B) by Continuous Infusion Platinum.- 23. Locally Advanced Paranasal Sinus and Nasopharyngeal Cancers - Effects of Hyperfractionated Radiation and Concomitant Continuous Infusion Cisplatin.- 24. Cisplatin plus Radiotherapy in Bladder Cancer.- 25. Small-Cell Carcinoma of the Lung.- 26. Non-Small-Cell Carcinoma of the Lung.- Section V Radiopotentiation by Combined Cisplatin and Continuous Infusion 5-Fluorouracil.- 27. Head and Neck Cancer.- 28. Combined Cisplatin and Concomitant Continuous Infusion 5-Fluorouracil and Accelerated Radiation in Advanced Head and Neck Cancer.- 29. Toxicity of Combined Cisplatin, Infusional 5-Fluorouracil and Concomitant Radiotherapy in Advanced Head and Neck Cancer.- 30. Esophageal Carcinoma.- 31. Adenocarcinoma of the Gastroesophageal Junction: Preoperative Cisplatin and Concomitant Continuous Infusion 5-Fluorouracil and Radiation Therapy.- 32. Efficacy of 5-Fluorouracil by Continuous Infusion and Other Agents as Radiopotentiators for Gynecological Malignancies.- Section VI Efficacy of Continuous Infusion Adriamycin as a Radiation Potentiator.- 33. Concomitant Continuous Infusion Adriamycin and Radiation: Evidence of Synergistic Effects in Soft Tissue Sarcomas.- 34. Infusion Adriamycin and Radiation in Hepatomas.- List of Contributors.