Trauma and exposure to toxic and infectious agents invariably lead to organ damage followed by significant morbidity and mortality. Although these conditions have typically been associated with the battlefield, today they are more prevalent in urban areas. The events of September 11,2001 have brought this problem to the forefront of national and international concern. The demand for solutions is justifiably high, and the research community needs to adjust its efforts appropriately. Combat Medicine is meant to be a concise manual for the young clinical or basic investigator who is studying organ injury following trauma or toxic or infectious assaults either in an urban or battlefield setting, with an emphasis on current research issues in emergency and military medicine. The aim of Combat Medicine is to inspire surgical and medical residents and fellows, as well as biology and biochemistry students and fellows, to pursue research careers in the fields of military, trauma, and emergency medicine. Combat Medicine is not intended to be an exhaustive review; rather it is an introduction to key principles of this field.

Includes supplementary material: sn.pub/extras

Klappentext
The events of September 11, 2001 have clearly demonstrated that the future pathologies of warfare will increasingly affect noncombatant populations on a large scale and require new levels of treatment expertise. In Combat Medicine: Basic and Clinical Research in Military, Trauma, and Emergency Medicine, highly accomplished clinical and basic investigators concisely review the leading research issues confronting emergency and military medicine today. These experts begin by presenting the latest thinking about the molecular and cellular mechanisms of trauma-apoptosis, abnormalities in nitric oxide production, complement activation, and immune cell response to stressors-that lead to tissue damage, and then describe cutting-edge research aimed at understanding and reversing the consequent damage to major organs. The clinical conditions covered include hemorrhagic shock and resuscitation, ischemia-reperfusion injury, acute respiratory distress syndrome, thermal injury, inhalation injury, and traumatic brain injury. The authors discuss the natures of combat pathologies, current research, emerging treatments, red blood cell storage, and bioterrorism involving anthrax, smallpox, plague, and other infectious and toxic agents.
Cutting-edge and timely, Combat Medicine: Basic and Clinical Research in Military, Trauma, and Emergency Medicine offers not only clinical and basic investigators, but also surgical and medical residents, a concise introduction to the principal clinical conditions encountered in emergency, disaster, and combat medicine, as well as an up-to-date statement of where our diagnostic and treatment programs now stand, and what we still need to learn for future preparedness.

Inhalt
I Basic Mechanisms.- 1 Apoptosis.- 2 Nitric Oxide.- 3 The Microcirculation and Adhesion Molecules.- 4 Heat Stress.- 5 Immune System.- 6 Complement Inhibitors in Trauma.- 7 Infections.- II Current Concepts.- 8 Hemorrhagic Shock and Resuscitation: Trauma Research at the Trauma Research and Readiness Institute for Surgery.- 9 Ischemia/Reperfusion Injury.- 10 Acute Respiratory Distress Syndrome.- 11 Thermal Injury.- 12 Inhalation Injury.- 13 Traumatic Brain Injury.- 14 Red Blood Cell Storage.- 15 Bioterrorism.