Reviews recent advances in cluster headache and trigeminal autonomic cephalgias Explains the neurobiology of various headache forms

Examines current and future approaches to treatment

Autorentext

Massimo Leone has been a neurologist at Carlo Besta Neurological Institute since 1985. Throughout the years he has helped to introduce the main treatments for cluster headache and other trigeminal autonomic cephalgias, including verapamil. He has been recognized by various Institutions for the introduction of deep brain stimulation in cluster headache and other trigeminal autonomic cephalgias, and has published 270 original articles. Since 2007 he has led the Neuromodulation Unit of the Neurological Department, Headache and Neuroalgology Centre at Carlo Besta Neurological Institute.  Arne May is a Professor of Neurology at the Department of Systems Neuroscience, University of Hamburg and head of the headache outpatient clinic and the facial outpatient clinic of the University Clinic of Hamburg. His major research interests are the basic mechanisms of facial and head pain, the chronification of pain and plasticity within the human brain. His group's work involves humanimaging studies in primary headache as well as experimental studies of trigeminovascular nociception, with the aim of understanding how to modulate facial and headache syndromes and chronicity of pain. Prior to his position at the University of Hamburg, Professor May was a clinician and conducted research on pain and headache syndromes at the University of Regensburg. Prior to this he completed his residency in the Neurology Department of the University of Essen, followed by post-doctorate studies at the Institute of Neurology in London. Professor May has been a member of the Board of Trustees of the International Headache Society since 2013, and has published over 300 original and review articles.

Inhalt

1 History and Epidemiology.- 2 Classification and clinical features.- 3 Differential diagnosis including secondary forms and headache forms in chapter 4 of the IHS classification.- 4 Genetics of cluster headache and related disorders.- 5 Pathophysiology of trigeminal autonomic cephalalgias.- 6 Neuroimaging.- 7 The nature of pain in trigeminal autonomic cephalgias: neuropathic? Nociceptive?.- 8 What role for the hypothalamus and diencephalic area.- 9 Animals models for trigeminal autonomic cephalalgias.- 10 CGRP: from headache mechanisms to monoclonal antibodies.- 11 The sphenopalatine ganglion: new insights.- 12 Pharmacological treatment.- 13 Neurostimulation: why, when, which one.- 14 Behavioral and psychological aspects.- 15 Neurophysiology.- 16 Indomethacin and trigeminal autonomic cephalalgias.- 17 Trigeminal neuralgia: channels, pathophysiology and therapeutic challenges.- 18 Maybe this one: Neurovascular headaches: migraine and cluster headache pathophysiology, differences and similarities.