This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson's Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center.
Cutting-edge and authoritative, Clinical Trials in Parkinson's Disease is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials.

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Inhalt
Toxin-Based Rodent Models of Parkinson's Disease.- Assessment of Non-Motor Symptoms in Rodent Models of Parkinson's Disease.- Genetic Models of Parkinson's Disease.- A Review of Randomized Phase III Pharmacological Clinical Trials for Motor Symptoms in Parkinson's Disease Patients and Quality of Evidence Recommendations.- Clinical Trials for Motor Complications in Parkinson's Disease.- Clinical Trials for Gait Disorders in Parkinson's Disease.- Clinical Trials for Disease Modifying Agents in Parkinson's Disease.- Value and Methods of Pharmacovigilance in the Monitoring of Drug Safety in Parkinson's Disease.- Clinical Trials for Cognitive Impairment and Dementia in Parkinson's Disease.- Clinical Trials for Depression, Anxiety, Fatigue, and Apathy in Parkinson's Disease.- Clinical Trials for Sleep Disorders and Daytime Somnolence in Parkinson's Disease.- Clinical Trials on Management of Pain in Parkinson's Disease.- Clinical Trials for Orthostatic Hypotension in Parkinson's Disease and Other Synucleinopathies.- Clinical Trials for Erectile Dysfunction in Parkinson's Disease.- Clinical Trials for Constipation in Parkinson's Disease.