This book considers chronic obstructive pulmonary disease (COPD) not as a simple inflammation of the lung but as a systemic inflammatory disease. Beginning with epidemiological studies, etiology, diagnosis and treatment, it elaborates further, illustrating some comorbidities and associations with other respiratory diseases. As such it provides numerous improved and more comprehensive treatment methods, including drug therapies as well as some non-drug therapies. There are also chapters describing the pathogenesis, genetic abnormalities and newly discovered pathogenetic mechanisms that are expected to be studied further in the future.

Edited and written by pioneering researchers, each chapter summarizes the latest trends, describes future prospects and explores the unresolved and critical questions. Chronic Obstructive Pulmonary Disease - A Systemic Inflammatory Disease is a valuable resource to beginning researchers, physicians engaged in clinical practice, supervisors, and basic researchers whose work includes COPD.

Autorentext
Editors

Hiroyuki Nakamura
Department of Respiratory Medicine
Tokyo Medical University Ibaraki Medical Center
Ibaraki, Japan

Kazutetsu Aoshiba
Department of Respiratory Medicine
Tokyo Medical University Ibaraki Medical Center
Ibaraki, Japan

Inhalt
Part IDefinition and Epidemiology.- 1.Definition of COPD.- 2.Epidemiology of COPD.- Part IIGenetic Predisposition and Pathogenic Mechanisms.- 3.Genetic predisposition to COPD.- 4.Pathogenesis of COPDPersistence of airway inflammation.- 5.Pathogenesis of COPD 3- Oxidative stress.- 6.Pathogenesis of COPD 4.- Part IIIComorbidities.- 7.Pathogenesis of comorbidities in COPD.- 8.Assessment of inflammation in COPD.- Part IVManagement and Treatment.- 9.Exercise therapy for COPD.- 10.Nutritional therapy for COPD.- 11.Home oxygen therapy for COPD.- 12.Bronchodilators for COPD.- 13.Inhaled corticosteroids for COPD.- 14.New anti-inflammatory drugs for COPD.- 15.Exacerbation of COPD.- Part VAssociations with other Respiratory Diseases.- 16.Asthma-COPD overlap syndrome (ACOS).- 17.Combined pulmonary fibrosis and emphysema (CPFE) .- 18.Association of COPD and lung cancer.