Chaperokine, is a term that describes the unique function of extracellular heat shock protein (eHsp) as both chaperone and cytokine. The cellular consequence of binding and signaling of eHsp is the stimulation of a potent and long lasting immune response. eHsp induces a plethora of immune responses including the release of bioactive mediators like cytokines, chemokines, nitric oxide, apotogenic mediator, stimulation of the innate and adaptive immune response, migration and maturation of dendritic cells (DC) and the enhancement of natural killer cell-mediated cellular cytotoxicity.

The book Chaperokine Activity of Heat Shock Proteins provides the most comprehensive review on contemporary knowledge on the chaperokine activity of heat shock proteins (HSP) in biology and medicine. Using an integrative approach to understanding the chaperokine activity of HSP, the contributors provide a synopsis of novel mechanisms, signal transduction pathways and how the principlesof the chaperokine activity of HSP has been harnessed for therapeutic gain.

To enhance the ease of reading and comprehension this book has been subdivided into various section, including; Section I, reviews current progress on our understanding of Immunological and Inflammatory Responses; Section II, evaluates the role of Physiological Responses and Section III, focuses the reader on the Therapeutic Approach. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychologists, Human Physiology, Zoologists, Botanists, Biotechnology, Molecular Medicine, Infectious Diseases Experts, Pathologists, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Provides the most comprehensive review of contemporary knowledge of the chaperokine activity of heat shock proteins (HSP) in biology and medicine Contains chapters contributed by specialists from key basic and clinical research laboratories at major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world An important source of reference for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychology, Human Physiology, Zoology, Botany, Biotechnology, Molecular Medicine, Infectious Disease, Pathology and Pharmaceutical Sciences, as well as for researchers involved in Drug Discovery.

Klappentext

Chaperokine is a term that describes the unique function of extracellular heat shock protein (eHsp) as both chaperone and cytokine. The cellular consequence of binding and signaling of eHsp is the stimulation of a potent and long lasting immune response. eHsp induces a plethora of immune responses including the release of bioactive mediators such as cytokines, chemokines, nitric oxide, apotogenic mediators, stimulation of the innate and adaptive immune response, migration and maturation of dendritic cells (DC) and the enhancement of natural killer cell-mediated cellular cytotoxicity.

This edited book provides the most comprehensive review of contemporary knowledge of the chaperokine activity of heat shock proteins (HSP) in biology and medicine. Using an integrative approach to understanding the chaperokine activity of HSP, the contributors provide an overview of novel mechanisms, signal transduction pathways and a concise understanding of how the principles of the chaperokine activity of HSP has been harnessed for therapeutic gain.

Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present cutting-edge research activities and importantly, the future direction of chaperokine research. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychology, Human Physiology, Zoology, Botany, Biotechnology, Molecular Medicine, Infectious Disease, Pathology and Pharmaceutical Sciences, as well as for researchers involved in Drug Discovery.

Inhalt
Chapter 1. Chaperokine Activity of Heat Shock Protein .- Chapter 2. Extracellular HSP70, Neuroinflammation and Protection against Viral Virulence .- Chapter 3. The Biology of Extracellular HSP60 .- Chapter 4. Heat Shock Protein 60: A Mediator of Atherosclerosis and its Potential Therapeutic Role .- Chapter 5. Role of Heat Shock Protein 90 in Autoimmune Inflammatory Rheumatic Diseases .- Chapter 6. Upregulation of Cytoprotective Chaperones Mediate Better Tolerance to High Altitude .- Chapter 7. Role of Chaperone Mediated Autophagy in Viral Infections .- Chapter 8. Chaperones in Sterile Inflammation and Injury .- Chapter 9. Chaperone in Inflammation and Immunomodulation: Resistin and PPlases .- Chapter 10. Exercise-induced Chaperokine Activity of Hsp70: Possible Role in Chronic Diseases .- Chapter 11. Physical Exercise and Heat Shock Proteins .- Chapter12. Extracellular Hsp90 Governs Spatio-temporal Regulation of Biological Responses .- Chapter 13. HSP47 and its Involvement in Fibrotic Disorders .- Chapter 14. Therapeutic Implications of Heat Shock Proteins in Cancer .- Chapter 15. Targeting Heat Shock Proteins for Immunotherapy .- Chapter 16. Modulation of Heat Shock Proteins by Natural Products.