This volume provides a comprehensive overview of the methodology, physiology, and contemporary and novel applications of cerebrovascular reactivity (CVR) measurements. The chapters in this book cover topics such as an introduction of the neurophysiology, neuroimaging, and clinical methods for CVR measurement; the use of CVR methods in the study of aging, cerebrovascular dysfunction, dementia, and brain tumors; and recommendations for measurement protocols and future applications in clinical translation. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation.

Thorough and comprehensive, Cerebrovascular Reactivity: Methodological Advances and Clinical Applications is a valuable tool that provides researchers in neuroscience and neurology with the latest resources on the measurement, interpretation, and application of CVR measurement.

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Inhalt
The Physiological Basis of Cerebrovascular Reactivity Measurements.- Experimental Protocols in CVR Mapping.- Molecular Imaging of Cerebrovascular Reactivity.- Measurement of Cerebrovascular Reactivity using Transcranial Doppler.- The Role of Cerebrovascular-Reactivity Mapping in Functional MRI: Calibrated fMRI and Resting-State fMRI.- Hemodynamic Evaluation of Paradoxical Blood Oxygenation-Level Dependent Cerebrovascular Reactivity with Transcranial Doppler and MR-Perfusion in Patients with Symptomatic Cerebrovascular Steno-Occlusive Disease.- Cerebrovascular Reactivity (CVR) in Aging, Cognitive Impairment, and Dementia.- Magnetic Resonance Imaging Methods for Assessment of Hemodynamic Reserve in Chronic Steno-Occlusive Cerebrovascular Disease.- Breath-Hold Cerebrovascular Reactivity Mapping for Neurovascular Uncoupling Assessment in Primary Gliomas.- Clinical Translation of Cerebrovascular Reactivity Mapping.- Recent Advances andFuture Directions: Clinical Applications of Intraoperative BOLD-MRI CVR.