This book presents the options available for the management of metabolic syndrome from the perspective of cardiac and renal medicine. Cardiovascular-kidney-metabolic (CKM) syndrome represents a complex interplay between cardiovascular diseases, metabolic conditions such as obesity and diabetes, and renal dysfunction. This multifaceted syndrome has gained significant attention in recent years due to its rising prevalence and profound implications for public health. Excessive body weight and insulin resistance contribute to increased cardiovascular risk and kidney dysfunction, creating a vicious cycle that exacerbates overall health outcomes. Understanding the pathophysiological mechanisms underlying CKM syndrome is essential for effective management. Key factors include chronic inflammation, oxidative stress and the dysregulation of hormones and metabolic pathways that not only affect cardiovascular health but also impair renal function. CKM syndrome can be conceptualized in various stages, each characterized by different severity and manifestations of the underlying conditions.

Cardiovascular-Kidney-Metabolic Syndrome provides a thorough review of the topic and presents a coherent strategy to manage the syndrome. With early identification crucial for timely intervention and to mitigate the progression of disease, this book discusses the use of routine assessments of cardiovascular health, renal function and metabolic parameters to facilitate early intervention and reduce the risk of severe complications.

To address the complex interactions within CKM syndrome, a multidisciplinary approach is therefore imperative. This book represents a key resource for the different specialties involved cardiology, nephrology and endocrinology ensuring that patients receive comprehensive care that addresses all facets of their condition.

Presents options for the management of metabolic syndrome within cardiac and renal medicine Characterizes metabolic syndrome from the perspective of the main affected organs Introduces a multidisciplinary team approach for cardiologists and nephrologists within existing metabolic medicine

Autorentext

Mariana Floria is Professor at Grigore T. Popa University of Medicine and Pharmacy, a Senior Consultant in Internal Medicine and Cardiologist at Emergency Clinical Hospital Sf. Spiridon Iäi, Romania. She had a Fellowship in arrhythmology (two years) and echocardiography (two years) at Catholic University of Louvain, in Belgium. Also, she has EACVI certification in transthoracic echocardiography (since 2015), being a Fellow of European Society of Cardiology. Professor Floria Mariana is Associate Editor at Echocardiography Journal (official journal of International Society of Cardiovascular Ultrasound) and Journal of Clinical Ultrasound: Sonography and other Imaging Techniques (JCU)She has over 137 papers on PubMed related to atrial fibrillation and other arrhythmias in patients with cardiac and metabolic comorbidities (Hirsh index: 19). Professor Floria Mariana has a particular interest (but not limited at) in cardiac rhythm disorders (especially atrial fibrillation), cardiovascular imaging (especially echocardiography) and metabolic disease.

Daniela Maria Tanase is an Associate Professor at the Grigore T. Popa University of Medicine and Pharmacy Iasi, Romania, a Senior Consultant in Internal Medicine, and a Clinical Cardiologist at Emergency Clinical Hospital Sf. Spiridon Iasi, Romania. She graduated from the Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iasi, in 2002. She has authored and co-authored several books, book chapters, and medical articles and served as the scientific coordinator of several works, including works written in Romanian and in English. She participates in medical congresses both in the country and abroad, as well as in national and international courses. Her research works (112 publications in Web of Science; H-Index: 18) are related to cardiovascular diseases, cardiovascular complications, atherosclerosis, oxidative stress, inflammatory bowel disease, nonalcoholic fatty liver disease, gut microbiota, dysbiosis, and type 2 diabetes.

Inhalt

Introduction.- The Evolution of Cardiovascular-Kidney-Metabolic Syndrome.- Epidemiology and Risk Factors in Cardiovascular-Kidney-Metabolic Syndrome.- Genetic and Molecular Aspects of Cardiovascular-Kidney-Metabolic Syndrome.- Pathophysiology and Mechanisms of Cardiovascular-Kidney-Metabolic Syndrome.- Inflammation and Oxidative Stress in Cardiovascular-Kidney-Metabolic Syndrome.- The Role of Gut Microbiota in Cardiovascular-Kidney-Metabolic Heath.- The Role of Insulin Resistance and Metabolic Dysregulation in Cardiovascular-Kidney-Metabolic Syndrome.- Diagnosis and Biomarkers of Cardiovascular-Kidney-Metabolic Syndrome.- Stages of Disease Progression in Cardiovascular-Kidney-Metabolic Syndrome.- Obesity as a Central Factor in Cardiovascular-Kidney-Metabolic Syndrome.- The Role of the Kidney in Cardiovascular-Kidney-Metabolic Syndrome.- The Role of the Heart in Cardiovascular-Kidney-Metabolic Syndrome.- Sarcopenia and Muscle Metabolism in Cardiovascular-Kidney-Metabolic Syndrome.- Sleep Disorders and Circadian Rhythm Disruptions in Cardiovascular-Kidney-Metabolic Syndrome.- Hematological Impact of Cardiovascular-Kidney-Metabolic Syndrome.- Prevention and Treatment Strategies in Cardiovascular-Kidney-Metabolic Syndrome.- Comprehensive Management Strategies for Cardiovascular-Kidney-Metabolic Syndrome.- Multidisciplinary Team Approaches and Future Perspectives for Cardiovascular-Kidney-Metabolic Syndrome.