Addresses the Resistance of Solid Tumors
to Anticancer Therapeutics

Cancer Drug Resistance represents a point on the path of the long journey toward understanding the complex interactions between host, tumor and cytotoxic or immunomodulatory agents. It addresses the resistance of solid tumors to anticancer therapeutics by considering mechanisms that involve alterations in genetics and epigenetics, cellular biochemistry, properties related to physiology of the solid tumor mass and alterations in host metabolic and immune status induced by the presence of malignant disease.

Includes supplementary material: sn.pub/extras

Inhalt
Physiological Resistance.- The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors.- Influence of Tumor pH on Therapeutic Response.- Tumor Oxygenation and Treatment Response.- Oncogenes and Tumor Suppressor Genes in Therapeutic Resistance.- PET Imaging of Response and Resistance to Cancer Therapy.- Biological Resistance.- Cancer Stem Cells Implications for Development of More Effective Therapies.- Therapeutic Resistance in Leukemia.- Tumor Site Implantation and Animal Model Selection in Oncology.- In Vivo Resistance.- Characteristics of the Metastatic Phenotype.- The Microenvironment and Drug Resistance.- Biochemical Resistance.- Glutathione and Glutathione S-Transferases in Drug Resistance.- Metallothioneins in Drug Resistance.- Molecular Determinants of Intrinsic Multidrug Resistance in Cancer Cells and Tumors.- New and Revised Concepts in Multidrug Resistance.- Cisplatin Resistance.- Regulation of the Cellular Pharmacology and Cytotoxicity of Cisplatin by Copper Transporters.- Resistance To Taxanes.- CpG Island Methylation and Drug Resistance.- De Novo and Acquired Resistance to Antitumor Alkylating Agents.- Resistance to Antiangiogenic Agents.- The Role of Hormones, Growth Factors, and Oncogenes.- Resistance to Antiestrogens.- Mechanisms of Glucocorticoid Actions and Resistance in Multiple Myeloma.- Herceptin Resistance.- Role of TGF-? in Tumor Progression and Metastasis.- p53-Based Immunotherapy of Cancer.- Response and Resistance to Ionizing Radiation.- Amplification in DNA Copy Numbers as a Mechanism of Acquired Drug Resistance.- Clinical Aspects of Resistance.- Cancer Chemotherapy.- Molecular Profiling in Breast Cancer.- Tumor Immune Escape Mechanisms.