New Advances and Directions in Cancer Immunotherapy

This book provides a general background as well as an overview and update of the use of cancer immunotherapy. Aside from highlighting new advances and directions in cancer immunotherapy; also covered are the most common forms of cancer immunotherapy, challenges in clinical trial design and the need for biomarkers of response.

Includes supplementary material: sn.pub/extras

Inhalt
Discovery of Target Molecules for Cancer Immunotherapy by Genetic and Bioinformatic Approaches.- Current Strategies for the Identification of Immunogenic Epitopes of Tumor Antigens.- Current and Future Role of Natural-Killer Cells in Cancer Immunotherapy.- The Role of Immune Monitoring in Evaluating Cancer Immunotherapy.- Statistical Analysis of Immune Response Assays in Cancer Immunotherapy Trials.- DNA Vaccines for Cancer Immunotherapy.- Dendritic Cells.- Different Approaches to Dendritic Cell-Based Cancer Immunotherapy.- Anti-Idiotype Antibody Vaccines for the Immunotherapy of Cancer.- Autologous Tumor-Derived Heat Shock Protein Vaccine as a New Paradigm for Individualized Cancer Therapeutics.- Tumor-Reactive T-Cells for Adoptive Immunotherapy.- T-Cell Adoptive Immunotherapy of Cancer.- Retroviral-Mediated Gene Transfer for Engineering Tumor-Reactive T-Cells.- Harnessing the Potential of Graft-vs-Tumor.- Tumor-Induced Immune Suppression and Immune Escape.- The Tumor Microenvironment.- Manipulation of Lymphocyte Homeostasis for Enhancing Antitumor Immunity.- Fast-Lane Evolution in the Tumor Microenvironment.- Manipulating Immunological Checkpoints to Maximize Antitumor Immunity.- Interleukin-2 as Cancer Therapy.- Biological and Clinical Properties of the Type 1 Interferons.- Promising ?-Chain Cytokines for Cancer Immunotherapy.- The Therapeutic Use of Natural-Killer Cells in Hematological Malignancies.- Antibody Therapy for Solid Tumors.- Antibody Therapy for Non-Hodgkin's Lymphoma.- Approaches to In Vivo Imaging of Cancer Immunotherapy.- Design Issues for Early-Stage Clinical Trials for Cancer Vaccines.- Monoclonal Antibody Therapy of Cancer.