Bone Metastasis and Molecular Mechanisms

Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer.

Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies.

Provides an overview of molecular factors that offer targets and avenues for therapeutic strategies

Inhalt
1 Models of Breast Cancer Metastasis to Bone: Characterization of a Clinically Relevant Model.- 2 Quantitation of Bone Metastasis in Experimental Systems.- 3 Comparative Morphometric Study on Bone Remodeling in Human Specimens and in Experimental Models of Metastatic Bone Disease.- 4 Clinical Modalities for the Diagnosis, Characterization and Detection of Bone Metastases.- 5 Metastasis in the Bone Marrow Microenviroment.- 6 The Role of Tumor-Associated Macrophages in Metastasis-Associated Osteolysis.- 7 The Malignant Hierarchy in Multiple Myeloma: Relationships between Malignant Cells and Bone Disease.- 8 Angiogenesis and Lymphangiogenesis in Metastatic Bone Disease: A Matter of Networking.- 9 Prostate Cancer: Models for Developing Novel Therapeutic Approaches.- 10 Potential Therapeutic Targets for Bone Metastasis.- 11 OPG, RANK and RANKL in Bone Metastasis and Cancer-Associated Osteolysis.- 12 Role of Matrix Metalloproteinases in Bone Metastasis from Human Breast and Prostate Cancer.- 13 The Role of Bisphosphonates in Bone Metastasis.