Biofilm-Mediated Diseases: Causes and Controls

This book reviews the current concepts in biofilm formation and its implications in human health and disease. The initial chapters introduce the mechanisms of biofilm formation and its composition. Subsequently, the chapters discuss the role of biofilm in acute and chronic infections. It also explores the pivotal role of both innate and adaptive immunity on the course of biofilm infection. In addition, the book elucidates the bacterial biofilm formation on implantable devices and the current approaches to its treatment and prevention. It analyzes the possible relationship between antimicrobial resistance and biofilm formation. Finally, the book also summarizes the current state-of-the-art therapeutic approaches for preventing and treating biofilms.

This book is a useful resource for researchers in the field of microbiology, clinical microbiology, and also medical practitioners.

Introduces the concept of biofilm formation and their role in bacterial pathogenesis

Explores close interconnection between biofilm development and quorum sensing

Highlights the strategies for combating bacterial biofilm infections

Discusses the prevalence of bacterial biofilm formation on medical devices

Autorentext

Rina RaniRay is working as an Associate Professor and Head, Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, West Bengal. Her research interest focusses on the diverse field of microbial biotechnology. She has published around 80 research papers in various peer reviewed national and international journals and is the editorial board member of various international journals. She is the member of various scientific associations and is fellow of Zoological Society, India and Academy for Environment and Life Sciences, India.

Moupriya Nag is presently working as an Assistant Professor at the Department of Biotechnology, University of Engineering & Management, Kolkata. Her research focuses on analysis of functional amyloids in bacteria and their relation in forming biofilms towards the development of novel antimicrobial and anti-biofilm compounds from natural sources including plants, microbes and green synthesized nanoparticles. She has also published many research articles in the peer-reviewed international journals and authored or co-authored numerous book chapters. She is also a member of many scientific societies like Indian Biophysical Society and Indian Science Congress Association.

Dibyajit Lahiri is working as an Assistant Professor at the Department of Biotechnology, University of Engineering & Management, Kolkata His research interest is precisely on biofilm isolated from human prosthesis and its inhibition by various novel phyto and nano-compounds. He is a life Member of Indian Science Congress Association and Institution of Engineers (India).

Inhalt
Chapter 1_ Bacterial and other acute Infections. - Chapter 1.1. Introduction to Bacterial biofilm. - Chapter 1.2. Planktonic and Biofilm growing bacteria. - Chapter 1.3. Quorum sensing and biofilm . - Chapter 1.4. Infection Pathogenesis. -Chapter 2 . Quorum sensing. - Chapter 2.1. Mechanism of quorum sensing in Gram positive and Gram negative bacteria. - Chapter 2.2. Quorum sensing molecules. - Chapter 2.3. Quorum sensing and virulence. - Chapter 2.4. Pharmacological perspective of quorum sensing. -Chapter 3. Bacteria and biofilms as natural inhabitants of our body. -Chapter 3.1. Oral Biofilms. -Chapter 3.2. Skin Microbiology. -Chapter 3.3. Commensal Biofilm Gut Flora. -Chapter 3.4. Other sites of Bacterial Biofilms in body. -Chapter 4. Role of Biofilms in acute and chronic infections. -Chapter 4.1. Biofilm in acute infection. -Chapter 4.2. Chronic Infections - Host response. -Chapter 4.3. Chronic Infections - Treatment failure. -Chapter 4.4. Chronic Infections Persistency. - Chapter 5 . Role of biofilms in nosocomial diseases. -Chapter 5.1. Biofilm and Cystic Fibrosis. -Chapter 5.2 Biofilm and Chronic Wounds. -Chapter 5.3. Biofilm and Endophthalmitis. -Chapter 5.4. Biofilm and Keratitis. - Chapter 6. Immune response to biofilm. -Chapter 6.1. Immune evasion by biofilm. -Chapter 6.2. Skewing of immune response. -Chapter 6.3. Local immune response. -Chapter 6.4. Systemic immune response. - Chapter 7. Biofilm in medical appliances. -Chapter 7.1. Biofilm and Implants. -Chapter 7.2. Biofilm in Tissue Fillers. -Chapter 7.3. Biofilm in Otitis Media. -Chapter 7.4. Biofilm in Intravascular Catheter. -Chapter 8 . Biofilm and antimicrobial resistance. -Chapter 8.1. Antibiotic resistance by biofilm. -Chapter 8.2. Mechanism of antibiotic resistance. -Chapter 8.3. Genetic basis of resistance- mobile genetic elements. -Chapter 8.4. Effects of antibiotic resistance. -Chapter 9. Inhibition of biofilm formation. -Chapter 9.1. Inhibition of quorum sensing and signalling pathways. -Chapter 9.2. Other interacting members in a bacterial biofilm. -Chapter 9.3. Natural antibiofilm compounds. -Chapter 9.4. Phytochemicals and biofilm. -Chapter 10 . Novel and Future Treatment Strategies for Biofilm associated infections. -Chapter 10.1. Phytomedicine. -Chapter 10.2. New antimicrobials. -Chapter 10.3. Nanoparticles/ Nanomedicine. -Chapter 10.4. Latest antibiotics in pipeline and antibiotic adjuvants.