Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature and this book covers the hot topics of frontier research summarized by reputed scientists in the field.

As part of the series Topics in Heterocyclic Chemistry,thisvolumetitledBio- tiveHeterocyclesII presentscomprehensiveandup-to-datereviewsonselected topicsconcerning?avonoidsandanthocyaninsinplants,andheterocyclessuch as bioactive phenothiazines, phenoxazines, and related compounds. The v- ume isseparated into two sections mainly concentrating onthese two topics. There are abundant and diverse ?avonoids with carbohydrates and lipids, alkaloids (betalain alkaloids and other alkaloids), phenols (chromones, c- marins,lignans,quinines,andotherphenolics),terpenoids(monoterpenoids, sesquiterpene lactones, triperpenoid saponins, carotenoids, and other t- penoids), and minerals as micronutritionalphytochemicals in fruits and v- etables of our daily diets. Among these phytochemicals, the ?avonoids have speci?c functionality in relation to age-related diseases such as hypertension, diabetes,cardiacinfarction,cataracts,andcancer.Theauthorsofeachchapter inthe?rst sectionhave presented their evidence in relationtothemechanism ofthepreventative andtherapeutic ability ofthecompounds. The ?rst chapter, Functionality of Anthocyanins as Alternative Medicine byNoboruMotohashiandHiroshiSakagami,presentstheirantioxidantme- anism for anthocyanidins, which are present in common foods. It is possible that anthocyanins may have been used both preventatively and clinically as part of many folklore medicines worldwide and may have provided heal- carebene?tssincetheappearanceofmankindsome7.5millionyearsago.The review willinform the reader as to their functionalityand mechanism. The second chapter, Bioactive Mechanism of Interaction between Ant- cyanins and Macromolecules Like DNA and Proteins by Seetharamappa J- dappagari, Noboru Motohashi, Mamatha P.Gangeenahalli, and James H. N- smith, presents the biological activities of anthocyanins, and the interactions of anthocyanins with DNA and protein. Anthocyanins might protect against damage to health by some types of harmful oxidants through various me- anisms such as their antioxidative activity, protein active site binding, and chelating complex formation. The review presents the interesting interactive mechanism of anthocyanin DNA complex formation.

Heterocyclic chemistry is the biggest branch of chemistry covering two-third of the chemical literature Covers hot topics of frontier research summarized by reputed scientists in the field Our review series is topic related Online version available on SpringerLink.com Includes supplementary material: sn.pub/extras

Inhalt

N. Motohashi, H. Sakagami: Functionality of Anthocyanins as Alterative Medicine.- S. Jaldappagari, N. Motohashi, M.P. Gangeenahalli, J.H. Naismith: Bioactive Mechanism of Interaction Between Anthocyanins and Macromolecules Like DNA and Proteins.- A. Dasgupta, S.G. Dastidar, Y. Shirataki, Noboru Motohashi: Antibacterial Activity of Artificial Phenothiazines and Isoflavones from Plants.- J. Molnár, H. Engi, N. Gyémánt, Z. Schelz, G. Spengler, I. Ocsovszki, M. Szücs, J. Hohmann, M. Szabo, L. Tanács , P. Molnár, J. Deli, L. Krenn, M. Kawase, H. Wakabayashi, T. Kurihara, Y. Shirataki, H. Sakagami, N. Motohashi, R. Didiziapetris: Multidrug Resistance of Cancer Cells by Selected Carotenoids, Flavonoids and Anthocyanins.- M. Kobayashi, H. Sakagami, M. Kawase, N. Motohashi: Changes in Polyamine Levels during Cell Death Induced by Heterocycles.- H. Sakagami, M. Kobayashi, M. Ishihara, H. Kikuchi, Y. Nakamura, M. Kawase, N. Motohashi: Tumor Specificity and Type of Cell Death induced by Heterocycles.- A. Shah, J. Bariwal, J. Molnár, M. Kawase, N. Motohashi: Advanced Dihydropyridines as Novel Multidrug Resistance Modifiers and Reversing Agents.- T. Kurihara, K. Shinohara, M. Inabe, H. Wakabayashi, N. Motohashi, H. Sakagami, J. Molnar: Theoretical Studies on Phenothiazines, Benzo[a]phenothiazines and Benz[c]acridines.