Despite millennia of proximity to, and consumption of products from, the Cannabis plant, we have an incomplete understanding of its behavioural impact. This volume presents current research summaries in three sections, focussing on contextualisation of the work at molecular and cellular levels, and behavioural paradigms for investigating Cannabis and cannabinoid preparations in non-human animals and humans. The contributors are leaders in their respective fields and internationally recognisable.

The book contents are unique in the progression that it encompasses the molecular understanding of cannabinoids through animal models of behaviour into humans. It reflects a resurgence in attempts to understand the potential therapeutic benefits of Cannabis and cannabinoid preparations. This is evidenced by the increasing number of countries/states where Cannabis -based products for medicinal use have been approved, as well as some notable locations where non-medicinal consumption of Cannabis preparations has been legalised.

Reflects the pervasiveness of Cannabis as a global drug of (ab)use Covers a wide spectrum of areas ranging from molecular to animal to humans Written by globally-recognized leaders in their fields

Inhalt

Preface.- Canonical Cannabinoid Receptors.- The pharmacological profile of plant-derived cannabinoids in vitro.- Chemical Probes for Exploiting the Endocannabinoid System.- Genetic Tools in Rodents to Study Cannabinoid Functions.- Pharmacotherapy for Cannabis Use Disorder: Preclinical and Clinical Models.- Delta-9-tetrahydrocannabinol and Cannabidiol for Pain: Preclinical and Clinical Models.- Neurodegeneration and ageing.- Cannabinoid-based pharmacology for the management of drug relapse.- The role of cannabinoids and the endocannabinoid system in the treatment and regulation of nausea and vomiting.- The use of cannabis-based medicine in selected neurological disorders.