Advances in Bladder Research

The aim of Bladder Research Congress, San Francisco, California, April 23-25, 1998, was to provide a forum for authoritative investigators who are actively involved in the various disciplines which define the leading edges of bladder research. It is important for such investigators to continue to meet regularly for the purpose of discussing the latest developments in their individual fields, to analyze the significance of current research, to discuss new tactics for unresolved problems, to critically evaluate current theories, and to develop new theories and approaches as needed. The two and a half day meeting was organized into five half day sessions, with each session encompassing one of five topics: (1) Epithelial-Mesenchymal Interactions; (2) Ex tracellular Matrix and Muscle; (3) Nerves and Pharmacology; (4) Infection and Immunol ogy; and (5) Oncology. Each session was introduced by a moderator followed by five to six invited expert speakers with time for extensive interaction from the participants. Two late-afternoon poster sessions allowed further interactions between investigators. This book documents the proceedings of the Bladder Research Congress. It is organ ized into the five half-day sessions of the meeting with moderators overview and an edited transcription of discussions that followed each presentation. I would like to thank Sarah Burke and the Office of Continuing Medical Education, USCF; Joanne Hayward, Editorial Assistant; and Miriam Escamilla, Administrative Assis tant. I hope you find this resource useful. Laurence S. Baskin, M.D.

Inhalt

1. Uroplakins as Markers of Urothelial Differentiation.- 2. Urothelial Tissue Regulation: Unraveling the Role of the Stroma.- 3. Creation of Bladder Tissue in Vitro and in Vivo: A System for Organ Replacement.- 4. Reconstruction of the Urinary Bladder by Auto-Augmentation, Enterocystoplasty, and Composite Enterocystoplasty.- 5. Epithelial-Mesenchymal Interactions in the Bladder: Implications for Bladder Augmentation.- 6. Serosal Thickening, Smooth Muscle Cell Growth, and Phenotypic Changes in the Rabbit Bladder Wall during Outflow Obstruction and Regeneration.- 7. Replicative Senescence in Human Uroepithelial Cells.- 8. Ultrastructural Smooth Muscle Ontogeny of the Rat Bladder.- 9. Fetal Bladder Physiology.- 10. Developmental Aspects of the Contractile Smooth Muscle Component in Small Intestinal Submucosa Regenerated Urinary Bladder.- 11. Contractile Protein Changes in Urinary Bladder Smooth Muscle following Outlet Obstruction.- 12. Calcium Ion Homeostasis in Urinary Bladder Smooth Muscle.- 13. Cyclooxygenase-2: A Key Regulator of Bladder Prostaglandin Formation.- 14. Role of Angiotensin II in Bladder Smooth Muscle Growth and Function.- 15. New Concepts on the Normal and Abnormal Developing Bladder.- 16. Biochemical and Physiological Characterization of the Urinary Bladder in Ehlers-Danlos Syndrome.- 17. The Role of Collagen in Bladder Filling.- 18. Pathways for Relaxation of Detrusor Smooth Muscle.- 19. Maturation of Bladder Reflex Pathways during Postnatal Development.- 20. Subcellular Distribution of Free Fatty Acids, Phospholipids, and Endogenous Lipase Activity of Rabbit Urinary Bladder Smooth Muscle and Mucosa.- 21. Effects of Glutamate Receptor Antagonists on Lower Urinary Tract Function in Conscious Unanesthetized Rats.- 22. Observations from the Spontaneously Hypertensive Rat: Insight into NGF Regulation and Noradrenergic Hyper-Innervation in the Lower Urinary Tract.- 23. Role of Na+-K+-ATPase Activity in Regulation of Detrusor Contractility and Diabetic Bladder Dysfunction.- 24. Restoration of Bladder Function in Spastic Neropathic Bladder Using Sacral Deafferentation and Different Techniques of Neurostimulation.- 25. Pathophysiology of Bacterial Cystitis.- 26. Role of Vaginal Colonization in Urinary Tract Infections (UTIs).- 27. Host Factors in Susceptibility to Urinary Tract Infections.- 28. Induction of Nitric Oxide Synthase with Urinary Tract Infections.- 29. Interferon Alpha for the Treatment of Superficial Bladder Cancer.- 30. Urokinase (u-PA) and the u-PA Receptor: Modulation of in Vitro Invasiveness of Human Bladder Cancer Cell Lines.- 31. The Role of Matrix Metalloproteinases in an in Vitro Model of Bladder Tumor Invasion.- 32. DNA Methylation in Development of Bladder Cancer.- 33. Cellular Proliferation and Cell-Cell Cycle Regulatory Proteins as Prognostic Markers for Transitional Cell Carcinoma of the Bladder.- 34. Urothelial Differentiation and Bladder Cancer.- 35. Complexity, Retinoid-Responsive Gene Networks, and Bladder Carcinogenesis.- 36. Tumor Cell Motility: A Novel Therapeutic Target in Bladder Carcinoma, Experimental and Clinical Results.