This new book extensively explores a range of topics related to astrocyte-neuron interactions under multiple conditions, in both health and disease. These include the types of interactions that occur during development and the establishment of neuronal circuits that underlie learning and memory formation in various animal models as well as humans. Furthermore, the book addresses topics on how these interactions go awry in disease and injury. In addition, the authors propose inspiring new avenues to explore therapeutic approaches using astrocytes as targets. A cadre of international experts presents a broad range of views on the state-of-the-art of astrocyte-neuron interactions.

Describes the new research into astrocytes as therapeutic targets Explores recent discoveries to explain how astrocytes and neurons interact to control multiple aspects of brain function Brings together international experts to offer a broad view from diverse researcher perspectives

Autorentext

Elena Blanco-Suarez, PhD, is an Assistant Professor in the Departments of Neuroscience and Neurological Surgery at the Vickie and Jack Farber Institute for Neuroscience in Thomas Jefferson University, Philadelphia.

Isabella Farhy-Tselnicker, PhD, is an Assistant Professor in the Department of Biology in Texas A&M University, College Station, Texas.

Drs. Blanco-Suarez and Farhy-Tselnicker trained together as postdoctoral fellows, becoming experts in astrocyte-neuron interactions during development and synaptic maturation in mouse models. In 2020, both started their independent careers as Assistant Professors. Dr. Blanco-Suarez's research focuses on the study of astrocyte-mediated neuroplasticity in the context of ischemic stroke, while Dr. Farhy-Tselnicker's lab investigates astrocyte-neuron interactions necessary to shape synapse development and activity. With this book, they brought in experts from across the globe to give current insights into how the crosstalk between astrocytes and neurons is essential for shaping the central nervous system and constitutes a very interesting target for future investigations in disease and injury.

Inhalt

Evolution of Astrocyte-Neuron Interactions across Species.- Glia in Invertebrate Models: Insights from C. elegans.- Astrocyte Development in the Rodent.- Neuron-Astrocyte Interactions: A Human Perspective.- Gene Expression at the Tripartite Synapse: Bridging the Gap between Neurons and Astrocytes.- Homeostasis to Allostasis: Prefrontal Astrocyte Roles in Cognitive Flexibility and Stress Biology.- Astrocyte-Neuron Interactions in Substance Use Disorders.- Astrocytes in Pain Perception: A Systems Neuroscience Approach.- Astrocyte-Neuron Interaction in Spinal Cord Injury.- Astrocyte Regulation of Neuronal Function and Survival in Stroke Pathophysiology.- The Interplay of Astrocytes and Neurons in Autism Spectrum Disorder.- Astrocyte-Neuron Interactions Contributing to Amyotrophic Lateral Sclerosis Progression.- The Role of Astrocytes in Parkinson's Disease.- Astrocyte-Neuron Interactions in Alzheimer's Disease.