This text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situation. The book explores pharmacodynamics methods for anti-infective agents, pharmacodynamics of antibacterial agents and non-antibacterial agents, as well as pharmacodynamic considerations and special populations. As part of the Methods in Pharmacology and Toxicology series, chapters include detailed insight and practical information for the lab. Comprehensive and cutting-edge, Antibiotic Pharmacodynamics serves as an ideal reference for scientists investigating advances in antibiotic pharmacodynamics now finding their way into the antibiotic development process used for licensing new antibiotics.

Forges a path toward new antibiotic development processes for licensing new antibiotics Offers state-of-the-art contributions from world renowned experts Explores how antibiotics might be optimally used in a clinical situation Features practical, reproducible methods and key implementation advice

Inhalt
General Concepts of Pharmacodynamics for Anti-Infective Agents.- In Vitro Pharmacodynamic Models to Evaluate Anti-Infective Pharmacodynamics.- Animal Models to Evaluate Anti-Infective Pharmacodynamics.- Pharmacodynamic Issues in Antibiotic Combinations.- Methodologies for Protein Binding Determination in Anti-Infective Agents.- Evaluation of Exposure-Response Relationships Using Clinical Data: Basic Concepts and Applications.- Toxicokinetics and Toxicodynamics of Anti-Infective Agents.- Pharmacodynamics of Fluoroquinolones.- Aminoglycoside Pharmacodynamics.- Polymyxin Pharmacokinetics and Pharmacodynamics.- Vancomycin Pharmacodynamics: Optimal vs. Controversial.- Pharmacodynamics of Lipoglycopeptides.- Pharmacodynamics of Daptomycin.- **** Newer Glycolipopeptides-Lipopeptides in Pharmacodynamics.- Pharmacodynamics of Macrolides, Azalides, and Ketolides.- Antifungal Pharmacokinetics and Pharmacodynamics.- Pharmacokinetics and Pharmacodynamics of the Tuberculosis Drugs.- Pharmacodynamics of Antimalarial Agents.- Pharmacodynamics of Antiviral Agents.- Pharmacodynamics of Antiretroviral Agents.- Implementing a Continuous or Prolonged Infusion Beta-Lactam Program in the Hospital Setting.- Pharmacodynamic Considerations in Critically Ill Patients.- Pharmacodynamic Considerations and Special Populations: Pediatrics.- Pharmacodynamics and Obesity.- Drug Development Process and Regulatory Science.- Antibiotic Stewardship and Applications of Pharmacodynamics.