Annette Barchanski deals with the question how to design nanoparticles for biomedical research. She considers properties such as size, charge, biocompatibility, and functionalization of nanoparticles from a biologist's point of view in order to achieve specific cellular responses. The author discusses the structure-function relationship of nanoparticle conjugates derived from a laser-based fabrication method. Both the limits and perspectives of tunable conjugate functions are presented, providing a general outline for researchers to configure functionalized nanoparticles with a specifically optimized design for biomedical requests, e.g. in biomedical engineering regenerative science and reproductive biology.

Includes supplementary material: sn.pub/extras

Autorentext

Annette Barchanski works as a scientific researcher at the Laser Zentrum Hannover e.V.

Inhalt

Nano-Revolution of Biomedical Science and Reproductive Biology.- Gold Nanoparticles: Optical and Toxicological Aspects; Membrane Interactions; Biological Application Areas.- Design Criteria and Laser-Based Fabrication of Gold Nanoparticles and Gold Nanoparticle Bioconjugates.- Yield Enhancement of Laser Ablation Method.- Structure-Function Relationship: Intrinsic Parameters of Gold Nanoparticles; Conjugation Parameters.- Laser-Based Fabrication and Bioconjugation of Silicon and Magnetic Nanoparticles.